{"id":6089,"date":"2021-07-28T00:53:04","date_gmt":"2021-07-27T15:53:04","guid":{"rendered":"https:\/\/www.hoe2021.com\/?p=6089"},"modified":"2021-12-20T17:50:20","modified_gmt":"2021-12-20T08:50:20","slug":"%e3%80%8c%e5%a6%8a%e5%a8%a020%e9%80%b1%e7%9b%ae%e3%81%be%e3%81%a7%e3%81%ab%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e6%89%93%e3%81%a3%e3%81%9f%e4%ba%ba%e3%81%ae%e6%b5%81%e7%94%a3%e7%8e%87-2","status":"publish","type":"post","link":"https:\/\/www.hoe2021.com\/?p=6089","title":{"rendered":"\u300c\u598a\u5a2020\u9031\u76ee\u307e\u3067\u306b\u30ef\u30af\u30c1\u30f3\u3092\u6253\u3063\u305f\u4eba\u306e\u6d41\u7523\u7387\u306f82%\u300d\u306f\u30c7\u30de"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 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ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.hoe2021.com\/?p=6089\/#%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E5%8F%82%E8%80%83%E8%A8%98%E4%BA%8B\" >\u305d\u306e\u4ed6\u306e\u53c2\u8003\u8a18\u4e8b<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.hoe2021.com\/?p=6089\/#mRNA%E3%83%AF%E3%82%AF%E3%83%81%E3%83%B3%E6%8E%A5%E7%A8%AE%E3%81%A782%E6%B5%81%E7%94%A3%E3%81%AE%E3%83%87%E3%83%9E%EF%BC%88kj%E6%B0%8F%EF%BC%89\" >mRNA\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306782%\u6d41\u7523\u306e\u30c7\u30de\uff08kj\u6c0f\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.hoe2021.com\/?p=6089\/#%E3%83%AF%E3%82%AF%E3%83%81%E3%83%B3%E3%81%A7%E5%A6%8A%E5%A9%A6%E3%81%AE82%E3%81%8C%E6%B5%81%E7%94%A3%E3%81%99%E3%82%8B%E3%81%A8%E3%81%84%E3%81%86%E3%83%87%E3%83%9E%E3%81%A8%E3%82%BD%E3%83%BC%E3%82%B9%E8%AB%96%E6%96%87%E3%81%AE%E8%AA%AD%E8%A7%A3%EF%BC%88pogemutaBN%E6%B0%8F%EF%BC%89\" >\u30ef\u30af\u30c1\u30f3\u3067\u598a\u5a66\u306e82%\u304c\u6d41\u7523\u3059\u308b\u3068\u3044\u3046\u30c7\u30de\u3068\u30bd\u30fc\u30b9\u8ad6\u6587\u306e\u8aad\u89e3\uff08pogemutaBN\u6c0f\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.hoe2021.com\/?p=6089\/#%E3%80%8CNEJM%E8%AB%96%E6%96%87%E3%81%AB%E3%82%88%E3%82%8C%E3%81%B0%E3%83%AF%E3%82%AF%E3%83%81%E3%83%B3%E6%8E%A5%E7%A8%AE%E3%82%92%E5%8F%97%E3%81%91%E3%81%9F%E5%A6%8A%E5%A9%A6%E3%81%AE%E6%B5%81%E7%94%A3%E7%8E%87%E3%81%8C82%EF%BC%85%E3%80%8D%E3%81%AF%E3%83%87%E3%83%9E%EF%BC%88%E4%BC%8A%E8%B3%80%E6%B2%BB%E6%B0%8F%EF%BC%89\" >\u300cNEJM\u8ad6\u6587\u306b\u3088\u308c\u3070\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u598a\u5a66\u306e\u6d41\u7523\u7387\u304c82\uff05\u300d\u306f\u30c7\u30de\uff08\u4f0a\u8cc0\u6cbb\u6c0f\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.hoe2021.com\/?p=6089\/#Fact_Check-Data_from_a_study_does_not_conclude_that_over_80_of_pregnancies_end_in_miscarriage_after_COVID-19_vaccinations_figures_taken_out_of_context%EF%BC%88REUTERS%EF%BC%89\" >Fact Check-Data from a study does not conclude that over 80% of pregnancies end in miscarriage after COVID-19 vaccinations; figures taken out of context\uff08REUTERS\uff09<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 id=\"i-0\"><span class=\"ez-toc-section\" id=\"%E3%83%87%E3%83%9E%E3%81%AE%E5%86%85%E5%AE%B9\"><\/span>\u30c7\u30de\u306e\u5185\u5bb9<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u6b21\u306e\u3088\u3046\u306a\u3001<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2104983\" target=\"_blank\" rel=\"noopener\">\u598a\u5a66\u306b\u5bfe\u3059\u308b\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u3092\u8abf\u3079\u305f\u8ad6\u6587\uff08\u4e88\u5099\u8abf\u67fb\uff09<\/a>\u306e\u8868\u3092\u6839\u62e0\u3068\u3057\u3066\u3001<\/p>\n<div class=\"say left\">\n<p class=\"faceicon\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/chara\/liar.png\" width=\"110\"><span><\/span><\/p>\n<div class=\"chatting\">\n<div class=\"sc\">\u598a\u5a20\u521d\u671f\uff08\u307e\u305f\u306f\uff12\uff10\u9031\u76ee\uff09\u307e\u3067\u306b\u30ef\u30af\u30c1\u30f3\u3092\u6253\u3063\u305f\u4eba\u306e\u6d41\u7523\u7387\u306f\uff18\uff12\uff05<\/div>\n<\/div><\/div>\n<p>\u3068\u4e3b\u5f35\u3059\u308b\u4eba\u304c\u3044\u307e\u3059\u304c\u3001\u30c7\u30de\u3067\u3059\u3002<\/p>\n<h2 id=\"i-1\"><span class=\"ez-toc-section\" id=\"%E3%83%87%E3%83%9E%E3%81%AE%E8%A9%B3%E7%B4%B0\"><\/span>\u30c7\u30de\u306e\u8a73\u7d30<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"small\"><strong>\u30c7\u30de\u30c3\u30bf\u30fc\u306e\u30c4\u30a4\u30fc\u30c8\u306e\u4f8b<br \/>\n<\/strong><\/span><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5517 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_9.png\" alt=\"\" width=\"581\" height=\"501\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_9.png 581w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_9-300x259.png 300w\" sizes=\"auto, (max-width: 581px) 100vw, 581px\"><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u30c7\u30de\u30c3\u30bf\u30fc\u304c\u30c7\u30de\u306e\u6839\u62e0\u3068\u3057\u3066\u3044\u308b\u8ad6\u6587\u304c\u3053\u3061\u3089\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2104983\" target=\"_blank\" rel=\"noopener\">Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons<\/a><\/p>\n<p>\u30c7\u30de\u30c3\u30bf\u30fc\u304c\u300c\u6d41\u7523\u7387\u306f\uff18\uff12\uff05\u300d\u306e\u6839\u62e0\u3068\u3057\u3066\u51fa\u3057\u3066\u308b\u8ad6\u6587\u4e2d\u306e\u8868\u304c\u3053\u3061\u3089\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_10.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5521 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_10.png\" alt=\"\" width=\"881\" height=\"717\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_10.png 881w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_10-300x244.png 300w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_10-768x625.png 768w\" sizes=\"auto, (max-width: 881px) 100vw, 881px\"><\/a><\/p>\n<p>\u4e0a\u8a18\u753b\u50cf\u306e\u4e2d\u3067\u30c7\u30de\u30c3\u30bf\u30fc\u304c\u8d64\u7dda\u3067\u56f2\u3063\u305f\u90e8\u5206\u3092\u307e\u3068\u3081\u308b\u3068\u3053\u3046\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_11.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5523\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_11.png\" alt=\"\" width=\"673\" height=\"263\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_11.png 673w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_11-300x117.png 300w\" sizes=\"auto, (max-width: 673px) 100vw, 673px\"><\/a><\/p>\n<p>\u65e5\u672c\u8a9e\u306b\u7ffb\u8a33\u3059\u308b\u3068\u3053\u3046\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_18-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5588\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_18-2.png\" alt=\"\" width=\"675\" height=\"328\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_18-2.png 675w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_18-2-300x146.png 300w\" sizes=\"auto, (max-width: 675px) 100vw, 675px\"><\/a><br \/>\n<span class=\"small\"><strong>\u203b\u56f3\u4e2d\u306e\u8d64\u7dda\u306b\u3042\u308b\u901a\u308a\u3001\u3053\u306e\u8868\u306e\u30c7\u30fc\u30bf\u306f\u3001\u598a\u5a20\u767b\u9332\u80053,958\u4eba\u306e\u3046\u3061\u3001\u598a\u5a20\u3092\u7d42\u3048\u305f827\u4eba\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u3067\u3059\u3002<\/strong><\/span><\/p>\n<div class=\"accordion main_c\"><input type=\"checkbox\" id=\"label75156\" class=\"accordion_input\"><label for=\"label75156\">\u753b\u50cf\u306e\u4e0b\u6bb5\u90e8\u5206\u306e\u30c6\u30ad\u30b9\u30c8<\/label><\/p>\n<div class=\"accordion_content\">\n<p><span class=\"haiiro\">\u2020 Data on pregnancy loss are based on 827 participants in the v-safe pregnancy registry who received an mRNA Covid-19 vaccine (BNT162b2 [Pfizer\u2013BioNTech] or mRNA-1273 [Moderna]) from December 14, 2020, to February 28, 2021, and who reported a completed pregnancy.<br \/>\n<\/span>\u2020 \u598a\u5a20\u640d\u5931\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u30012020\u5e7412\u670814\u65e5\uff5e2021\u5e742\u670828\u65e5\u306e\u9593\u306b mRNA \u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\uff08BNT162b2\uff3b\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff3d\u307e\u305f\u306fmRNA-1273\uff3b\u30e2\u30c7\u30eb\u30ca\uff3d\uff09\u3092\u63a5\u7a2e\u3057\u3001v-safe\u306b\u598a\u5a20\u767b\u9332\u3057\u3001\u598a\u5a20\u3092\u7d42\u3048\u305f<span class=\"keiko_red\"><strong>827\u4eba\u306e\u53c2\u52a0\u8005<\/strong><\/span>\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">A total of 700 participants (84.6%) received their first eligible dose in the third trimester.<br \/>\n<\/span>\u3053\u306e\u3046\u3061<span class=\"keiko_red\"><strong>700\u4eba\u306e\u53c2\u52a0\u8005<\/strong>\uff0884.6\uff05\uff09\u304c\u598a\u5a20\u306e\u7b2c3\u671f\u306b\u6700\u521d\u306e<strong>\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e<\/strong><\/span>\u3057\u307e\u3057\u305f\uff08\u203b\u30d6\u30ed\u30b0\u4e3b\u306e\u88dc\u8db3\uff1a\u6b8b\u308a\u306e127\u4eba\u306f\u7b2c1\u671f\u306e\u76f4\u524d\uff5e\u7b2c2\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u307e\u3057\u305f\uff09\u3002<\/p>\n<div class=\"memo \">\n<div class=\"memo_ttl dfont\"> \u7c73\u56fd\u306e\u598a\u5a20\u671f\u9593\u306e\u533a\u5206<\/div>\n<ul>\n<li>\u7b2c1\u671f\u20260\uff5e12\u9031<\/li>\n<li>\u7b2c2\u671f\u202613\uff5e24\u9031<\/li>\n<li>\u7b2c3\u671f\u202625\u9031\u304b\u3089\u5206\u5a29\u307e\u3067<\/li>\n<\/ul>\n<\/div>\n<p><span class=\"haiiro\">Data on neonatal outcomes are based on 724 live-born infants, including 12 sets of multiples.<\/span><br \/>\n\u65b0\u751f\u5150\u306e\u8ee2\u5e30\uff08\u75c7\u72b6\u30fb\u72b6\u614b\u306e\u7d4c\u904e\u3084\u7d50\u679c\uff09\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u3001724\u4eba\u306e\u751f\u7523\u5150\uff0812\u7d44\u306e\u591a\u80ce\u5150\u3092\u542b\u3080\uff09\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">\u2021 A total of 96 of 104 spontaneous abortions (92.3%) occurred before 13 weeks of gestation.<\/span><br \/>\n\u2021 104\u4ef6\u4e2d96\u4ef6\u306e\u81ea\u7136\u6d41\u7523\uff0892.3\uff05\uff09\u304c\u598a\u5a2013\u9031\u524d\u306b\u767a\u751f\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>\u30c7\u30de\u30c3\u30bf\u30fc\u306e\u4e3b\u5f35\u3092\u518d\u63b2\u3057\u307e\u3059\u3002<\/p>\n<div class=\"say left\">\n<p class=\"faceicon\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/chara\/liar.png\" width=\"110\"><span><\/span><\/p>\n<div class=\"chatting\">\n<div class=\"sc\">\u598a\u5a20\uff12\uff10\u9031\u76ee\u307e\u3067\u306b\u6253\u3063\u305f\u4eba\u306f\uff11\uff12\uff17\u4eba\u3001\u6d41\u7523\u3057\u305f\u306e\u306f\uff11\uff10\uff14\u4eba\u3001\u3060\u304b\u3089\u6d41\u7523\u7387\u306f\uff11\uff10\uff14\uff0f\uff11\uff12\uff17\u2252\uff18\uff12\uff05<\/div>\n<\/div><\/div>\n<p>\u300c\uff11\uff12\uff17\u4eba\u300d\u3068\u3044\u3046\u6570\u5b57\u304c\u3069\u3053\u304b\u3089\u51fa\u3066\u304d\u305f\u304b\u3068\u3044\u3046\u3068\u3001\u4e0b\u306e\u753b\u50cf\u306e\u4e0b\u6bb5\u306b\u3042\u308b\u300c\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\uff08\u4e2d\u7565\uff09\u3092\u63a5\u7a2e\u3057\uff08\u4e2d\u7565\uff09\u598a\u5a20\u3092\u7d42\u3048\u305f\uff18\uff12\uff17\u4eba\u306e\u53c2\u52a0\u8005\u300d\u300c\uff17\uff10\uff10\u4eba\u306e\u53c2\u52a0\u8005\uff08\uff18\uff14\uff0e\uff16\uff05\uff09\u304c\u598a\u5a20\u306e\u7b2c\uff13\u671f\u306b\u6700\u521d\u306e\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u300d\u3068\u3044\u3046\u3068\u3053\u308d\u3067\u3059\u306d\u3002<\/p>\n<p>\u300c\u30ef\u30af\u30c1\u30f3\u3092\u6253\u3063\u305f\uff18\uff12\uff17\u4eba\u306e\u53c2\u52a0\u8005\u300d\u304b\u3089\u300c\u598a\u5a20\u306e\u7b2c\uff13\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\uff17\uff10\uff10\u4eba\u300d\u3092\u5f15\u304f\u3068\u3001\u300c<span class=\"keiko_red\">\u598a\u5a20\uff12\uff10\u9031\u76ee\u307e\u3067\uff08\u598a\u5a20\u306e\u7b2c\uff11\u671f\u306e\u76f4\u524d\uff5e\u7b2c\uff12\u671f\uff09\u306b\uff08\u30ef\u30af\u30c1\u30f3\u3092\uff09\u6253\u3063\u305f\u4eba\u306f<strong>\uff11\uff12\uff17\u4eba<\/strong><\/span>\u300d\u3068\u306a\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_12-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5577\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_12-4.png\" alt=\"\" width=\"675\" height=\"328\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_12-4.png 675w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_12-4-300x146.png 300w\" sizes=\"auto, (max-width: 675px) 100vw, 675px\"><\/a><\/p>\n<p>\u3067\u3001\uff08\u598a\u5a20\uff12\uff10\u9031\u76ee\u307e\u3067\u306b\uff09\u300c\u6d41\u7523\u3057\u305f\u306e\u306f<strong>\uff11\uff10\uff14\u4eba<\/strong>\u300d\u3068\u3044\u3046\u6570\u5b57\u306f\u3053\u3053\u304b\u3089\u53d6\u3063\u3066\u307e\u3059\u306d\u3002<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_14-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5576\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_14-1.png\" alt=\"\" width=\"675\" height=\"122\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_14-1.png 675w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-05_14-1-300x54.png 300w\" sizes=\"auto, (max-width: 675px) 100vw, 675px\"><\/a><\/p>\n<ul>\n<li>\u598a\u5a20\uff12\uff10\u9031\u76ee\u307e\u3067\u306b\u30ef\u30af\u30c1\u30f3\u3092\u6253\u3063\u305f\u4eba\u304c\uff11\uff12\uff17\u4eba<\/li>\n<li>\u598a\u5a20\uff12\uff10\u9031\u76ee\u307e\u3067\u306b\u6d41\u7523\u3057\u305f\u4eba\u304c\uff11\uff10\uff14\u4eba<\/li>\n<\/ul>\n<p>\u3060\u304b\u3089<\/p>\n<div class=\"say left\">\n<p class=\"faceicon\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/chara\/liar.png\" width=\"110\"><span><\/span><\/p>\n<div class=\"chatting\">\n<div class=\"sc\">\u598a\u5a20\uff12\uff10\u9031\u76ee\u307e\u3067\u306b\u30ef\u30af\u30c1\u30f3\u3092\u6253\u3063\u305f\u4eba\u304c\u6d41\u7523\u3059\u308b\u78ba\u7387\u306f\u3001\uff11\uff10\uff14\uff0f\uff11\uff12\uff17\u2252\uff18\uff12\uff05<\/div>\n<\/div><\/div>\n<p>\u3068\u3044\u3046\u4e3b\u5f35\u3067\u3059\u3002<\/p>\n<h2 id=\"i-2\"><span class=\"ez-toc-section\" id=\"%E3%83%87%E3%83%9E%E3%83%83%E3%82%BF%E3%83%BC%E3%81%AE%E8%A8%88%E7%AE%97%E3%81%8C%E9%96%93%E9%81%95%E3%81%84%E3%81%A7%E3%81%82%E3%82%8B%E7%90%86%E7%94%B1\"><\/span>\u30c7\u30de\u30c3\u30bf\u30fc\u306e\u8a08\u7b97\u304c\u9593\u9055\u3044\u3067\u3042\u308b\u7406\u7531<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u8ad6\u6587\u4e2d\u306b\u6570\u5b57\u304c\u305f\u304f\u3055\u3093\u51fa\u3066\u304f\u308b\u306e\u3067\u3001\u3061\u3087\u3063\u3068\u5206\u304b\u308a\u306b\u304f\u3044\uff08\u3084\u3084\u3053\u3057\u3044\uff09\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u5b9f\u969b\u306f\u5358\u7d14\u306a\u8a71\u3067\u3059\u3002<\/p>\n<p><strong>\u30c7\u30de\u30c3\u30bf\u30fc\u306f\u3001\u8a08\u7b97\u5f0f\u306e\u5206\u6bcd\u3092\u9593\u9055\u3048\u3066\u307e\u3059\u3002<\/strong><\/p>\n<p>\u3057\u3064\u3053\u3044\u3088\u3046\u3067\u3059\u304c\u3001\u3082\u3046\uff11\u5ea6\u3001\u30c7\u30de\u30c3\u30bf\u30fc\u306e\u8a08\u7b97\u5f0f\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<div class=\"say left\">\n<p class=\"faceicon\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/chara\/liar.png\" width=\"110\"><span><\/span><\/p>\n<div class=\"chatting\">\n<div class=\"sc\">\u598a\u5a20\uff12\uff10\u9031\u76ee\u307e\u3067\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u306f\uff11\uff12\uff17\u4eba\uff08\u598a\u5a20\u3092\u7d42\u3048\u305f<strong>\uff18\uff12\uff17\u4eba<\/strong>\uff0d\u7b2c\uff13\u671f\u63a5\u7a2e\uff17\uff10\uff10\u4eba\uff09\u3001\u6d41\u7523\u3057\u305f\u306e\u306f\uff11\uff10\uff14\u4eba\uff08\u7b2c\uff11\u671f\u6d41\u7523\uff19\uff16\u4eba\uff0b\u7b2c\uff12\u671f\u6d41\u7523\uff18\u4eba\uff09\u3001\u3060\u304b\u3089\uff12\uff10\u9031\u76ee\u307e\u3067\u306e\u6d41\u7523\u7387\u306f\uff11\uff10\uff14\uff0f\uff11\uff12\uff17\u2252\uff18\uff12\uff05<\/div>\n<\/div><\/div>\n<p>\u3067\u3001\u4e0b\u306e\u56f3\u3092\u898b\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210727_212219.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6293 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210727_212219.png\" alt=\"\" width=\"790\" height=\"444\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210727_212219.png 790w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210727_212219-300x169.png 300w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210727_212219-768x432.png 768w\" sizes=\"auto, (max-width: 790px) 100vw, 790px\"><\/a><\/p>\n<p>\u305d\u3082\u305d\u3082\u3001<span class=\"keiko_red\">\u8abf\u67fb\u5bfe\u8c61\u306e\u6bcd\u6570\u306f<strong>\uff13\uff0c\uff19\uff15\uff18\u4eba<\/strong><\/span>\u306a\u3093\u3067\u3059\u3002\u30c7\u30de\u30c3\u30bf\u30fc\u306e\u4e3b\u5f35\u306f\u3001\u307e\u308b\u3067\u3001\u300c\u598a\u5a20\u3092\u7d42\u3048\u305f\uff18\uff12\uff17\u4eba\u300d\u304c\u8abf\u67fb\u5bfe\u8c61\u306e\u6bcd\u6570\u3060\u3063\u305f\u304b\u306e\u3088\u3046\u306a\u8a00\u3044\u65b9\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u7b2c\uff11\u671f\u30fb\u7b2c\uff12\u671f\u306e<span class=\"keiko_red\">\u81ea\u7136\u6d41\u7523<strong>\uff11\uff10\uff14\u4eba\uff08\uff19\uff16\uff0b\uff18\uff09\u3068\u3044\u3046\u6570\u306f\u3001\uff13\uff0c\uff19\uff15\uff18\u4eba\u3092\u8abf\u67fb\u3057\u305f\u304b\u3089\u3053\u305d\u51fa\u3066\u304d\u305f<\/strong>\u6570\u5b57<\/span>\u3067\u3059\u3088\u3002<span class=\"keiko_red\">\uff18\uff12\uff17\u4eba\u3092\u8abf\u67fb\u3057\u3066\u81ea\u7136\u6d41\u7523\uff11\uff10\uff14\u4eba\u304c\u898b\u3064\u304b\u3063\u305f\u308f\u3051<strong>\u3067\u306f\u306a\u304f<\/strong>\u3001\u598a\u5a20\u3092\u7d42\u3048\u305f\u4eba\uff08\u81ea\u7136\u6d41\u7523\uff11\uff10\uff14\u4eba\uff0b\u6b7b\u7523\uff11\u4eba\uff0b\u4e2d\u7d76\u306a\u3069\uff11\uff10\u4eba\uff0b\u51fa\u7523\uff17\uff11\uff12\u4eba\uff09\u3092\u5408\u8a08\u3057\u305f\u3089\uff18\uff12\uff17\u4eba\u306b\u306a\u3063\u305f<\/span>\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p>\u3088\u308a\u5177\u4f53\u7684\u306b\u8aac\u660e\u3057\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\uff11\uff10\uff14\u4eba\u306e\u81ea\u7136\u6d41\u7523\u304c\u8d77\u304d\u305f\u7b2c\uff11\u671f\u30fb\u7b2c\uff12\u671f\u306b\u304a\u3044\u3066\u3001\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u306e\u306f\uff11\uff12\uff17\u4eba\uff08\u30c7\u30de\u30c3\u30bf\u30fc\u306e\u8a08\u7b97\u5f0f\u306e\u5206\u6bcd\uff09\u3060\u3051\u3067\u3057\u3087\u3046\u304b\uff1f \u3044\u3044\u3048\u3002\u305d\u306e\u3068\u304d\u306b\u598a\u5a20\u7d99\u7d9a\u4e2d\u3060\u3063\u305f\u4eba\uff08\u4e0a\u56f3\u306e\u9ec4\u8272\u3044\u90e8\u5206\uff09\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u598a\u5a20\u7d99\u7d9a\u4e2d\u3060\u3063\u305f\u4eba\u3082\u542b\u3081\u308b\u3068\uff08\u53d7\u80ce\u524d\u5f8c\u3082\u542b\u3081\u3066\uff09<strong>\u7b2c\uff11\u671f\u30fb\u7b2c\uff12\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u306f\u3001\u5408\u8a08\uff12\uff0c\uff19\uff13\uff18\u4eba<\/strong>\uff0892 + 1,132 + 1,714\uff09\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><strong><span class=\"small\">\u8ad6\u6587\u4e2d\u306e\u300c\u88683\u3000V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u53c2\u52a0\u8005\u306e\u7279\u5fb4\u300d\u3088\u308a<\/span><br \/>\n<\/strong><strong><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210725_213526-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6193 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210725_213526-1.png\" alt=\"\" width=\"793\" height=\"284\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210725_213526-1.png 793w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210725_213526-1-300x107.png 300w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/shot_210725_213526-1-768x275.png 768w\" sizes=\"auto, (max-width: 793px) 100vw, 793px\"><\/a><\/strong><\/p>\n<p>\u300c\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u306e\u7b2c\uff11\u671f\u30fb\u7b2c\uff12\u671f\u306b\u304a\u3051\u308b\u6d41\u7523\u78ba\u7387\u300d\u3092\u7b97\u51fa\u3057\u305f\u3044\u306e\u3067\u3042\u308c\u3070\u3001\u7b2c\uff11\u671f\u30fb\u7b2c\uff12\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u7dcf\u4eba\u6570\u3092\u5206\u6bcd\u306b\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u305d\u3046\u3067\u3059\u306d\uff1f<\/p>\n<ul>\n<li>\u3064\u307e\u308a\u3001\u300c<strong>\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u306e\u7b2c\uff11\u671f\u30fb\u7b2c\uff12\u671f\u306b\u304a\u3051\u308b\u81ea\u7136\u6d41\u7523\u78ba\u7387<\/strong>\u300d\u306f\u3001\u3053\u306e\uff12\uff0c\uff19\uff13\uff18\u4eba\u3092\u5206\u6bcd\u3068\u3057\u3066\u8a08\u7b97\u3059\u308c\u3070\u3001\uff11\uff10\uff14\uff0f\uff12\uff0c\uff19\uff13\uff18\u2252<strong>\uff13\uff0e\uff15\uff05<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<li>\u3064\u3044\u3067\u306b\u3001\u300c<strong>\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u306e\u7b2c\uff11\u671f\u306b\u304a\u3051\u308b\u81ea\u7136\u6d41\u7523\u78ba\u7387<\/strong>\u300d\u3082\u51fa\u3057\u3066\u307f\u308b\u3068\u3001\uff19\uff16\uff0f\uff11\uff0c\uff12\uff12\uff14\uff0892 + 1,132\uff09\u2252<strong>\uff17\uff0e\uff18\uff05<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>\u305f\u3060\u3057\u3001\u3053\u308c\u306f<strong>\u78ba\u5b9a\u5024\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong>\u3002\u3053\u306e\u8ad6\u6587\u306f\u8abf\u67fb\u304c\u5b8c\u4e86\u3057\u3066\u3044\u306a\u3044\u6bb5\u968e\u3067\u767a\u8868\u3055\u308c\u305f\u300c\u4e88\u5099\u8abf\u67fb\u300d\u3067\u3042\u308a\u3001\u8ad6\u6587\u306e\u767a\u8868\u6642\u70b9\u306b\u304a\u3044\u3066\u598a\u5a20\u7d99\u7d9a\u4e2d\u306e\u4eba\u304c\u307e\u3060\uff13\uff0c\uff11\uff13\uff11\u4eba\u3082\u3044\u3066\u3001\u305d\u306e\u4eba\u9054\u306e\u30c7\u30fc\u30bf\u3092\u542b\u3081\u305f\u5b8c\u5168\u306a\u30c7\u30fc\u30bf\u304c\u63c3\u3046\u306e\u306f\uff08\u3053\u306e\u8ad6\u6587\u767a\u8868\u6642\u306e\uff09\u307e\u3060\u5148\u306e\u3053\u3068\u3067\u3059\u3002\u305d\u3046\u3044\u3046\u610f\u5473\u3067\u3082\u3001\u3053\u306e\u300c\u4e88\u5099\u8abf\u67fb\u300d\u306e\u8ad6\u6587\u3092\u6839\u62e0\u3068\u3057\u3066\u78ba\u5b9a\u7684\u306a\u3053\u3068\u3092\u8a00\u3046\u306e\u306f\u9069\u5207\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u78ba\u5b9a\u7684\u306a\u306e\u306f\u3001\u30c7\u30de\u30c3\u30bf\u30fc\u306e\u300c\u81ea\u7136\u6d41\u7523\u7387\uff18\uff12\uff05\u300d\u3068\u3044\u3046\u6570\u5b57\u304c\u30c7\u30bf\u30e9\u30e1\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002<\/p>\n<h2 id=\"i-3\"><span class=\"ez-toc-section\" id=\"%E5%8F%82%E8%80%83\"><\/span>\u53c2\u8003<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 id=\"i-4\"><span class=\"ez-toc-section\" id=\"%E3%83%95%E3%82%A1%E3%82%AF%E3%83%88%E3%83%81%E3%82%A7%E3%83%83%E3%82%AF%E8%A8%98%E4%BA%8B\"><\/span>\u30d5\u30a1\u30af\u30c8\u30c1\u30a7\u30c3\u30af\u8a18\u4e8b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span class=\"haiiro\">Debunked: No, 82% of women vaccinated against Covid-19 in the first third of pregnancy don\u2019t miscarry<\/span><br \/>\n<a href=\"https:\/\/www.thejournal.ie\/pregnant-women-covid-vaccine-82-first-trimester-factcheck-5495371-Jul2021\/\" target=\"_blank\" rel=\"noopener\">\u300c\u598a\u5a20\u521d\u671f\u306b\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5973\u6027\u306e82%\u304c\u6d41\u7523\u3057\u305f\u3068\u3044\u3046\u306e\u306f\u30c7\u30de\u300d<\/a><\/p>\n<p><span class=\"haiiro\">the research that was published in that journal does not say this<\/span><br \/>\n\u305d\u306e\u30b8\u30e3\u30fc\u30ca\u30eb\u306b\u63b2\u8f09\u3055\u308c\u305f\u7814\u7a76\u306f\u305d\u306e\u3088\u3046\u306a\u3053\u3068\u306f\uff08\u81ea\u7136\u6d41\u7523\u7387\uff18\uff12\uff05\u306a\u3069\u3068\u306f\uff09\u8ff0\u3079\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">What the research actually found was that just 12.6% of the women involved in the study whose pregnancies had ended by the time of publication had experienced a miscarriage.<\/span><br \/>\n\u8abf\u67fb\u304b\u3089\u5b9f\u969b\u306b\u5224\u660e\u3057\u305f\u3053\u3068\u306f\u3001\u8abf\u67fb\u306e\u767a\u8868\u307e\u3067\u306b\u598a\u5a20\u3092\u7d42\u3048\u3066\u3044\u305f\u598a\u5a66\u306e12.6\uff05\u306e\u307f\u304c\u6d41\u7523\u3092\u7d4c\u9a13\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">The 82% figure is incorrect, because claimants have cherry-picked data that does not account for all pregnancies involved in the study.<\/span><br \/>\n82\uff05\u3068\u3044\u3046\u6570\u5b57\u306f\u6b63\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u306a\u305c\u306a\u3089\u3001\u8abf\u67fb\u306b\u95a2\u308f\u308b\u4ed6\u306e\u598a\u5a20\u304c\u7121\u8996\u3055\u308c\u3001\u6063\u610f\u7684\u306b\u30c7\u30fc\u30bf\u304c\u30d4\u30c3\u30af\u30a2\u30c3\u30d7\u3055\u308c\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">The remaining women \u2013 over 3,100 people \u2013 were still pregnant or had not followed-up with the study\u2019s authors by the time the research was published.<\/span><br \/>\n\u7814\u7a76\u306e\u767a\u8868\u6642\u70b9\u3067\u306f\u3001<strong>\u305d\u306e\u4ed6\u306e\u5973\u6027\uff083,100\u4eba\u4ee5\u4e0a\uff09\u306f\u307e\u3060\u598a\u5a20\u4e2d\u3067\u3042\u308b\u304b\u3001\u8abf\u67fb\u3078\u306e\u56de\u7b54\u3092\u3057\u3066\u3044\u307e\u305b\u3093<\/strong>\u3002<\/p>\n<p><span class=\"haiiro\">Again, these 827 cases referred only to the number of women whose pregnancies were completed at the time the research was published.<\/span><br \/>\n\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308a\u307e\u3059\u304c\u3001<strong>\u3053\u306e827\u4eba\u3068\u3044\u3046\u306e\u306f\u3001\u7814\u7a76\u306e\u767a\u8868\u524d\u306b\u598a\u5a20\u3092\u7d42\u3048\u305f\u5973\u6027\u306e\u307f<\/strong>\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">There is nothing in the research that says women who were vaccinated in the first and second trimesters were more susceptible to miscarriages than those vaccinated in the third trimester.<\/span><br \/>\n\u7814\u7a76\u3067\u306f\u3001\u7b2c1\u671f\u30fb\u7b2c2\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5973\u6027\u304c\u7b2c3\u671f\u306b\u63a5\u7a2e\u3057\u305f\u5973\u6027\u3088\u308a\u3082\u6d41\u7523\u3057\u3084\u3059\u3044\u306a\u3069\u3068\u306f\u793a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">That does not mean they were the only women vaccinated at that stage:<\/span><br \/>\n<strong>\u540c\u3058\u6642\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5973\u6027\u304c\u5f7c\u5973\u305f\u3061\u3060\u3051\u3068\u306f\u9650\u308a\u307e\u305b\u3093<\/strong>\u3002<\/p>\n<p><span class=\"haiiro\">an additional 3,000 pregnancies \u2013 involving a large number of women who were vaccinated at the same time as those who miscarried \u2013 were not recorded as complete in the study.<\/span><br \/>\n<strong>\u4ed6\u306e3,000\u4eba\u306e\u598a\u5a66\uff08\u6d41\u7523\u3057\u305f\u5973\u6027\u3068\u540c\u6642\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u591a\u6570\u306e\u5973\u6027\u3092\u542b\u3080\uff09\u304c\u3001\u598a\u5a20\u3092\u7d42\u3048\u305f\u3068\u306f\u8a18\u9332\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/strong>\u3002<\/p>\n<p><span class=\"haiiro\">We do not actually know the pregnancy outcomes of many women who were vaccinated in the first trimester, because they have not given birth yet.<\/span><br \/>\n<strong>\u598a\u5a20\u7b2c1\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5973\u6027\u306e\u591a\u304f\u306f\u3001\u307e\u3060\u598a\u5a20\u3092\u7d99\u7d9a\u4e2d\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u598a\u5a20\u306e\u7d50\u679c\u306f\u5b9f\u969b\u306b\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093<\/strong>\u3002<\/p>\n<p><span class=\"haiiro\">So it is not reasonable to deduce the effects of vaccination on women who got an mRNA vaccine in early pregnancy based on 127 outcomes alone.<\/span><br \/>\n\u3057\u305f\u304c\u3063\u3066\u3001127\uff08\u598a\u5a20\u3092\u7d42\u3048\u305f\u4eba\u306e\u3046\u3061\u7b2c\uff11\u671f\u30fb\u7b2c\uff12\u671f\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3057\u305f\u4eba\uff09\u306e\u7d50\u679c\u3060\u3051\u306b\u57fa\u3065\u3044\u3066\u3001\u598a\u5a20\u521d\u671f\u306bmRNA\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5973\u6027\u306b\u304a\u3051\u308b\u30ef\u30af\u30c1\u30f3\u306e\u52b9\u679c\u3092\u63a8\u6e2c\u3059\u308b\u306e\u306f\u6b63\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">Doing this assumes that these 127 women were the only people involved in the study who were vaccinated in the first and second trimester, when this is not the case.<\/span><br \/>\n\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f127\u4eba\u3092\u5206\u6bcd\u3068\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u598a\u5a20\u7b2c1\u671f\u3068\u7b2c2\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5973\u6027\u304c\u3053\u306e127\u4eba\u306e\u307f\u3067\u306a\u3051\u308c\u3070\u3044\u3051\u307e\u305b\u3093\u304c\u3001\u5b9f\u969b\u306f\u305d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">Only 12.6% of women who had completed their pregnancies by the time the study was published had experienced a miscarriage \u2013 a proportion that is in line with usual rates.<\/span><br \/>\n\u7814\u7a76\u306e\u767a\u8868\u307e\u3067\u306b\u598a\u5a20\u3092\u7d42\u3048\u305f\u5973\u6027\u306e12.6\uff05\u3060\u3051\u304c\u6d41\u7523\u3092\u7d4c\u9a13\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u901a\u5e38\u306e\u5272\u5408\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3 id=\"i-5\"><span class=\"ez-toc-section\" id=\"V-safe%E3%81%AE%E4%BB%95%E7%B5%84%E3%81%BF\"><\/span>V-safe\u306e\u4ed5\u7d44\u307f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u3001\u30b9\u30de\u30db\u304b\u3089\u767b\u9332<\/li>\n<li>\u30c6\u30ad\u30b9\u30c8\u30e1\u30c3\u30bb\u30fc\u30b8\u3068Web\u8abf\u67fb\u306b\u3088\u308a\u63a5\u7a2e\u5f8c\u306e\u6709\u5bb3\u4e8b\u8c61\u3092\u5831\u544a<\/li>\n<li>\u91cd\u8981\u306a\u5065\u5eb7\u88ab\u5bb3\u304c\u5831\u544a\u3055\u308c\u305f\u5834\u5408\u3001\u96fb\u8a71\u3067\u78ba\u8a8d<\/li>\n<li>\u598a\u5a20\u306e\u78ba\u8a8d\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u598a\u5a66\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u3067\u304d\u308b<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/V-safe.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6132\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/V-safe.png\" alt=\"\" width=\"815\" height=\"526\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/V-safe.png 815w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/V-safe-300x194.png 300w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/V-safe-768x496.png 768w\" sizes=\"auto, (max-width: 815px) 100vw, 815px\"><\/a><\/p>\n<p><a href=\"https:\/\/www.cov19-vaccine.mhlw.go.jp\/qa\/pdf\/0027_2.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cov19-vaccine.mhlw.go.jp\/qa\/pdf\/0027_2.pdf<\/a><br \/>\n<a href=\"https:\/\/www.cdc.gov\/vaccines\/acip\/meetings\/downloads\/slides-2021-02\/28-03-01\/05-covid-Shimabukuro.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cdc.gov\/vaccines\/acip\/meetings\/downloads\/slides-2021-02\/28-03-01\/05-covid-Shimabukuro.pdf<\/a><\/p>\n<h3 id=\"i-6\"><span class=\"ez-toc-section\" id=\"V-safe%E5%A6%8A%E5%A8%A0%E3%83%AC%E3%82%B8%E3%82%B9%E3%83%88%E3%83%AA3958%E4%BA%BA%E3%81%8C%E7%99%BB%E9%8C%B2%E3%81%95%E3%82%8C%E3%81%9F%E3%81%A8%E3%81%8D%E3%81%AE%E6%B5%81%E3%82%8C\"><\/span>V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea3,958\u4eba\u304c\u767b\u9332\u3055\u308c\u305f\u3068\u304d\u306e\u6d41\u308c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"tl\">\n<div class=\"tl-content main-bdr\">\n<div class=\"tl_label\">STEP.1<\/div>\n<div class=\"tl_title\">V-safe\u767b\u9332\u8005<\/div>\n<div class=\"tl_main\">\n<p>2020\u5e7412\u670814\u65e5\uff5e2021\u5e742\u670828\u65e5\u306e\u9593\u306b\u3001V-safe\u767b\u9332\u8005\u306e\u3046\u3061\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6e08\u307f\u3067\u3001\u598a\u5a20\u3057\u3066\u3044\u305f\u306e\u306f35,691\u4eba\u3002<\/p>\n<\/div>\n<div class=\"tl_marker main-bdr main-bc\"><\/div>\n<\/div>\n<div class=\"tl-content main-bdr\">\n<div class=\"tl_label\">STEP.2<\/div>\n<div class=\"tl_title\">\u9023\u7d61<\/div>\n<div class=\"tl_main\">\n<p>\u305d\u306e\u3046\u3061\u30015,230\u4eba\uff08\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6642\u306b\u598a\u5a20\u3057\u3066\u3044\u305f\u304b\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u3059\u3050\u5f8c\u3067V-safe\u8abf\u67fb\u4e2d\u306b\u598a\u5a20\u3057\u305f\u4eba\uff09\u306b\u9023\u7d61<\/p>\n<ul>\n<li>\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u304b\u306a\u308a\u524d\u306b\u598a\u5a20\u3057\u3066\u3044\u305f\u4eba\u306f\u9664\u5916<\/li>\n<li>\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u304b\u306a\u308a\u5f8c\u306b\u598a\u5a20\u3057\u3066\u3044\u305f\u4eba\u306f\u9664\u5916<\/li>\n<\/ul>\n<\/div>\n<div class=\"tl_marker main-bdr main-bc\"><\/div>\n<\/div>\n<div class=\"tl-content main-bdr\">\n<div class=\"tl_label\">STEP.3<\/div>\n<div class=\"tl_title\">V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u767b\u9332<\/div>\n<div class=\"tl_main\">\n<p>V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u767b\u9332\u57fa\u6e96\u3092\u30af\u30ea\u30a2\u3057\u3066V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u767b\u9332\u3055\u308c\u305f\u306e\u306f3,958\u4eba\uff08\u598a\u5a20\u4e2d\u307e\u305f\u306f\u53d7\u80ce\u524d\u5f8c\u306e\u6a5f\u95a2\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\uff09\u3002<\/p>\n<\/div>\n<div class=\"tl_marker main-bdr main-bc\"><\/div>\n<\/div>\n<\/div>\n<h3 id=\"i-7\"><span class=\"ez-toc-section\" id=\"%E3%80%8C%E6%9C%89%E5%AE%B3%E4%BA%8B%E8%B1%A1%E3%80%8D%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6\"><\/span>\u300c\u6709\u5bb3\u4e8b\u8c61\u300d\u306b\u3064\u3044\u3066<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>V-Safe\u3084VAERS\u306b\u95a2\u3059\u308b\u8a71\u984c\u3067\u306f\u3001\u300c\u6709\u5bb3\u4e8b\u8c61\uff08adverse event\uff09\u300d\u3068\u3044\u3046\u8a00\u8449\u304c\u3088\u304f\u51fa\u3066\u304d\u307e\u3059\u304c\u3001\u3053\u308c\u306f<span class=\"keiko_red\">\u30ef\u30af\u30c1\u30f3\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u304c\u8a8d\u3081\u3089\u308c\u305f\u3082\u306e\uff08\u539f\u56e0\uff09<strong>\u3067\u306f\u306a\u3044<\/strong><\/span>\u3068\u3044\u3046\u70b9\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>\u30ef\u30af\u30c1\u30f3\u306e\u672c\u5f53\u306e\u5bb3\u3092\uff08\u3082\u3057\u3042\u3063\u305f\u5834\u5408\u306f\uff09\u898b\u9003\u3055\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u305f\u3081\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u8d77\u304d\u305f\u4e00\u898b\u7121\u95a2\u4fc2\u3068\u601d\u308f\u308c\u308b\u3088\u3046\u306a\u6709\u5bb3\u306a\u4e8b\u8c61\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u305f\u3068\u3048\u3070\u4ea4\u901a\u4e8b\u6545\u3084\u843d\u96f7\u306b\u3088\u308b\u88ab\u5bb3\u306a\u3069\u3082\u5831\u544a\u5bfe\u8c61\u3068\u306a\u308a\u5f97\u308b\uff09\u3002<\/p>\n<p>\u53c2\u8003\u8a18\u4e8b\uff1a<a href=\"https:\/\/www.hoe2021.com\/?p=1063\">\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\u306e\u30c7\u30fc\u30bf\u3092\u51fa\u3057\u3066 \u201c\u30ef\u30af\u30c1\u30f3\u306f\u5371\u967a\u3060\u201d \u3068\u4e3b\u5f35\u3059\u308b\u306e\u306f\u4e0d\u9069\u5207<\/a><\/p>\n<h3 id=\"i-8\"><span class=\"ez-toc-section\" id=\"%E8%AB%96%E6%96%87%E3%81%AE%EF%BC%88%E3%81%BB%E3%81%BC%EF%BC%89%E5%85%A8%E8%A8%B3\"><\/span>\u8ad6\u6587\u306e\uff08\u307b\u307c\uff09\u5168\u8a33<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Google\u7ffb\u8a33\u3092\u30d9\u30fc\u30b9\u306b\u3057\u3066\u30d6\u30ed\u30b0\u4e3b\u304c\u4fee\u6b63\u3092\u5165\u308c\u305f\u3001\u8ad6\u6587\u306e\u65e5\u672c\u8a9e\u8a33\u3067\u3059\u3002<\/p>\n<p><strong><span class=\"haiiro big\">Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons<\/span><\/strong><br \/>\n<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2104983\" target=\"_blank\" rel=\"noopener\"><strong><span class=\"big\">\u598a\u5a66\u306b\u5bfe\u3059\u308bmRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u4e88\u5099\u7684\u8abf\u67fb<\/span><\/strong><\/a><\/p>\n<p>&nbsp;<\/p>\n<hr>\n<p><span class=\"big\"><strong><span class=\"haiiro\">Abstract<\/span><\/strong><\/span><br \/>\n<span class=\"big\"><strong>\u6982\u8981<\/strong><\/span><\/p>\n<hr>\n<p><strong><span class=\"haiiro\">BACKGROUND<\/span><\/strong><br \/>\n<strong>\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9<\/strong><\/p>\n<p><span class=\"haiiro\">Many pregnant persons in the United States are receiving messenger RNA (mRNA) coronavirus disease 2019 (Covid-19) vaccines, but data are limited on their safety in pregnancy.<\/span><br \/>\n\u7c73\u56fd\u306e\u591a\u304f\u306e\u598a\u5a66\u304cmRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u598a\u5a20\u4e2d\u306b\u304a\u3051\u308b\u5b89\u5168\u6027\u306e\u30c7\u30fc\u30bf\u306f\uff08\u307e\u3060\uff09\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong><span class=\"haiiro\">METHODS<\/span><\/strong><br \/>\n<strong>\u30e1\u30bd\u30c3\u30c9<\/strong><\/p>\n<p><span class=\"haiiro\">From December 14, 2020, to February 28, 2021, we used data from the\u201cv-safe after vaccination health checker\u201dsurveillance system, the v-safe pregnancy registry, and the Vaccine Adverse Event Reporting System (VAERS) to characterize the initial safety of mRNA Covid-19 vaccines in pregnant persons.<\/span><br \/>\n2020\u5e7412\u670814\u65e5\u304b\u30892021\u5e742\u670828\u65e5\u307e\u3067\u3001<strong>V-safe \u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u30d8\u30eb\u30b9\u30c1\u30a7\u30c3\u30ab\u30fc<\/strong>\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3001<strong>V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea<\/strong>\u3001\u304a\u3088\u3073<strong>\u30ef\u30af\u30c1\u30f3\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\uff08VAERS\uff09<\/strong>\u306e\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u3066\u3001\u598a\u5a66\u306b\u304a\u3051\u308bmRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u521d\u671f\u306e\u5b89\u5168\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><strong><span class=\"haiiro\">RESULTS<\/span><\/strong><br \/>\n<strong>\u7d50\u679c<\/strong><\/p>\n<p><span class=\"haiiro\">A total of 35,691 v-safe participants 16 to 54 years of age identified as pregnant.<\/span><br \/>\nV-safe\u53c2\u52a0\u8005\u306e\u5408\u8a0835,691\u4eba\uff0816\u301c54\u6b73\uff09\u304c\u598a\u5a20\u3057\u3066\u3044\u308b\u3068\u7279\u5b9a\u3055\u308c\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Injection-site pain was reported more frequently among pregnant persons than among nonpregnant women, whereas headache, myalgia, chills, and fever were reported less frequently.<\/span><br \/>\n\u6ce8\u5c04\u90e8\u4f4d\u306e\u75db\u307f\u306f\u3001\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\u3088\u308a\u3082\u598a\u5a20\u3057\u3066\u3044\u308b\u4eba\u306e\u9593\u3067\u3088\u308a\u983b\u7e41\u306b\u5831\u544a\u3055\u308c\u305f\u304c\u3001\u982d\u75db\u3001\u7b4b\u8089\u75db\u3001\u60aa\u5bd2\u3001\u304a\u3088\u3073\u767a\u71b1\u306e\u5831\u544a\u306f\u3080\u3057\u308d\u5c11\u306a\u304b\u3063\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Among 3958 participants enrolled in the v-safe pregnancy registry, 827 had a completed pregnancy, of which 115 (13.9%) resulted in a pregnancy loss and 712 (86.1%) resulted in a live birth (mostly among participants with vaccination in the third trimester).<\/span><br \/>\nV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u767b\u9332\u3055\u308c\u305f3,958\u4eba\u306e\u53c2\u52a0\u8005\u306e\u3046\u3061\u3001827\u4eba\u304c\u598a\u5a20\u3092\u7d42\u3048\u305f\u3002\u305d\u306e\u3046\u3061115\u4eba\uff0813.9\uff05\uff09\u304c\u6d41\u7523\u306b\u306a\u308a\u3001712\u4eba\uff0886.1\uff05\uff09\u304c\u51fa\u7523\u3057\u305f\uff08\u307b\u3068\u3093\u3069\u306f\u7b2c\uff13\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u53c2\u52a0\u8005\uff09\u3002<\/p>\n<p><span class=\"haiiro\">Adverse neonatal outcomes included preterm birth (in 9.4%) and small size for gestational age (in 3.2%); no neonatal deaths were reported.<\/span><br \/>\n\u65b0\u751f\u5150\u306e\u6709\u5bb3\u306a\u8ee2\u5e30\u306b\u306f\u3001\u65e9\u7523\uff089.4\uff05\uff09\u3068\u5728\u80ce\u4e0d\u5f53\u904e\u5c0f\uff083.2\uff05\uff09\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u65b0\u751f\u5150\u6b7b\u4ea1\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">Although not directly comparable, calculated proportions of adverse pregnancy and neonatal outcomes in persons vaccinated against Covid-19 who had a completed pregnancy were similar to incidences reported in studies involving pregnant women that were conducted before the Covid-19 pandemic.<\/span><br \/>\n\u76f4\u63a5\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u3066\u598a\u5a20\u3092\u7d42\u3048\u305f\u4eba\u306e\u6709\u5bb3\u306a\u598a\u5a20\u3068\u65b0\u751f\u5150\u8ee2\u5e30\u306e\u5272\u5408\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306e\u524d\u306b\u5b9f\u65bd\u3055\u308c\u305f\u3001\u598a\u5a66\u3092\u8abf\u67fb\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u5831\u544a\u3067\u306e\u767a\u751f\u7387\u3068\u540c\u69d8\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Among 221 pregnancy-related adverse events reported to the VAERS, the most frequently reported event was spontaneous abortion (46 cases).<\/span><br \/>\nVAERS\u306b\u5831\u544a\u3055\u308c\u305f221\u306e\u598a\u5a20\u95a2\u9023\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u4e2d\u3067\u3001\u6700\u3082\u983b\u7e41\u306b\u5831\u544a\u3055\u308c\u305f\u4e8b\u8c61\u306f\u81ea\u7136\u6d41\u7523\u3067\u3057\u305f\uff0846\u4f8b\uff09\u3002<\/p>\n<p><strong><span class=\"haiiro\">CONCLUSIONS<\/span><\/strong><br \/>\n<strong>\u7d50\u8ad6<\/strong><\/p>\n<p><span class=\"haiiro\">Preliminary findings did not show obvious safety signals among pregnant persons who received mRNA Covid-19 vaccines.<\/span><br \/>\n\u4e88\u5099\u8abf\u67fb\u306e\u7d50\u679c\u3067\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u598a\u5a66\u306e\u9593\u3067\u660e\u3089\u304b\u306a\u5b89\u5168\u6027\u306e\u61f8\u5ff5\u306f\u793a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">However, more longitudinal follow-up, including follow-up of large numbers of women vaccinated earlier in pregnancy, is necessary to inform maternal, pregnancy, and infant outcomes.<\/span><br \/>\n\u305f\u3060\u3057\u3001\u6bcd\u89aa\u3001\u598a\u5a20\u3001\u304a\u3088\u3073\u4e73\u5150\u306e\u8ee2\u5e30\u306b\u3064\u3044\u3066\u306e\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306b\u3001\u3088\u308a\u9577\u671f\u7684\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\uff08\u598a\u5a20\u521d\u671f\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u591a\u6570\u306e\u5973\u6027\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3092\u542b\u3080\uff09\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<hr>\n<p><span class=\"haiiro\"><span class=\"sobig\">T<\/span>he first coronavirus disease 2019 (Covid-19) vaccines available in the United States were messenger RNA (mRNA) vaccines: BNT162b2 (Pfizer\u2013BioNTech) and mRNA-1273 (Moderna).<\/span><br \/>\n\u7c73\u56fd\u3067\u6700\u521d\u306b\u5229\u7528\u53ef\u80fd\u306b\u306a\u3063\u305f\u65b0\u578b\u30b3\u30ed\u30ca\uff08Covid-19\uff09\u7528\u306e\u30ef\u30af\u30c1\u30f3\u306f\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\uff08mRNA\uff09\u30ef\u30af\u30c1\u30f3\uff08BNT162b2\uff3b\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff3d\u304a\u3088\u3073mRNA-1273\uff3b\u30e2\u30c7\u30eb\u30ca\uff3d\uff09\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">In December 2020, the vaccines were granted Emergency Use Authorization (EUA) by the Food and Drug Administration (FDA) as a two-dose series, 3 weeks apart for Pfizer\u2013BioNTech and 1 month apart for Moderna, and were recommended for use by the Advisory Committee on Immunization Practices (ACIP).<\/span><br \/>\n2020\u5e7412\u6708\u3001\u30ef\u30af\u30c1\u30f3\u306fFDA\uff08\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff09\u304b\u30892\u56de\u306e\u63a5\u7a2e\u30921\u30bb\u30c3\u30c8\u3068\u3057\u3066\u7dca\u6025\u4f7f\u7528\u8a31\u53ef\uff08EUA\uff09\u304c\u4e0e\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u4f7f\u7528\u9593\u9694\u306f\u3001ACIP\uff08\u4e88\u9632\u63a5\u7a2e\u306e\u5b9f\u65bd\u306b\u95a2\u3059\u308b\u8aee\u554f\u59d4\u54e1\u4f1a\uff09\u306e\u63a8\u5968\u3067\u306f\u3001\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\u306f3\u9031\u9593\u3001\u30e2\u30c7\u30eb\u30ca\u306f1\u304b\u6708\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Pregnant persons were excluded from preauthorization clinical trials, and only limited human data on safety during pregnancy were available at the time of authorization.<\/span><br \/>\n\u598a\u5a66\u306f\u4e8b\u524d\u627f\u8a8d\u306e\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u9664\u5916\u3055\u308c\u3066\u3044\u305f\u305f\u3081\u3001\u30ef\u30af\u30c1\u30f3\u627f\u8a8d\u6642\u306b\u598a\u5a66\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">However, pregnant persons with Covid-19 are at increased risk for severe illness (e.g., resulting in admission to an intensive care unit, extracorporeal membrane oxygenation, or mechanical ventilation) and death, as compared with nonpregnant persons of reproductive age.<\/span><br \/>\n\u305f\u3060\u3057\u3001\u598a\u5a20\u4e2d\u306b\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3059\u308b\u3068\u3001\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u4eba\uff08\u53d7\u80ce\u80fd\u529b\u304c\u3042\u308b\u4eba\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u91cd\u5ea6\u306e\u75c5\u6c17\uff08\u96c6\u4e2d\u6cbb\u7642\u5ba4\u3067\u306e\u6cbb\u7642\u3001ECMO\uff3b\u4f53\u5916\u5f0f\u819c\u578b\u4eba\u5de5\u80ba\uff3d\u3001\u307e\u305f\u306f\u4eba\u5de5\u547c\u5438\u5668\u306a\u3069\uff09\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Furthermore, pregnant persons with Covid-19 might be at increased risk for adverse pregnancy outcomes, such as preterm birth, as compared with pregnant persons without Covid-19.<\/span><br \/>\n\u3055\u3089\u306b\u3001\u598a\u5a20\u4e2d\u306b\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3057\u305f\u4eba\u306f\u3001\u611f\u67d3\u3057\u3066\u3044\u306a\u3044\u598a\u5a66\u3068\u6bd4\u8f03\u3057\u3066\u3001\u65e9\u7523\u306a\u3069\u306e\u6709\u5bb3\u306a\u598a\u5a20\u8ee2\u5e30\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">The Centers for Disease Control and Prevention (CDC) and ACIP, in collaboration with the American College of Obstetricians and Gynecologists and the American Academy of Pediatrics, have issued guidance indicating that Covid-19 vaccines should not be withheld from pregnant persons.<\/span><br \/>\nCDC\uff08\u7c73\u56fd\u75be\u75c5\u4e88\u9632\u7ba1\u7406\u30bb\u30f3\u30bf\u30fc\uff09\u3068ACIP\uff08\u4e88\u9632\u63a5\u7a2e\u306e\u5b9f\u65bd\u306b\u95a2\u3059\u308b\u8aee\u554f\u59d4\u54e1\u4f1a\uff09\u306f\u3001\u7c73\u56fd\u7523\u79d1\u5a66\u4eba\u79d1\u5b66\u4f1a\u304a\u3088\u3073\u7c73\u56fd\u5c0f\u5150\u79d1\u5b66\u4f1a\u3068\u5354\u529b\u3057\u3066\u3001\u598a\u5a66\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u3092\u63a7\u3048\u308b\u3079\u304d\u3067\u306f\u306a\u3044\u3068\u3059\u308b\u30ac\u30a4\u30c0\u30f3\u30b9\u3092\u767a\u884c\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Postauthorization monitoring in pregnant persons is necessary to characterize the safety of these new Covid-19 vaccines, which use mRNA, lipid nanoparticles, and state-of-the-art manufacturing processes.<\/span><br \/>\n\u30ef\u30af\u30c1\u30f3\u627f\u8a8d\u5f8c\u306e\u598a\u5a66\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306f\u3001mRNA\uff0f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff0f\u6700\u5148\u7aef\u306e\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u3092\u63a1\u7528\u3057\u3066\u3044\u308b\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u5b89\u5168\u6027\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Furthermore, establishing their safety profiles is critical to inform recommendations on maternal vaccination against Covid-19.<\/span><br \/>\n\u3055\u3089\u306b\u3001\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u306e\u30c7\u30fc\u30bf\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u306f\u3001\u598a\u5a66\u306b\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u3092\u4fc3\u3059\u305f\u3081\u306b\u3082\u91cd\u8981\u306a\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">We report preliminary findings of mRNA Covid-19 vaccine safety in pregnant persons from three U.S. vaccine safety monitoring systems: the \u201cv-safe after vaccination health checker\u201d surveillance system, the v-safe pregnancy registry, and the Vaccine Adverse Event Reporting System (VAERS).<\/span><br \/>\n\u7c73\u56fd\u306e3\u3064\u306e\u30ef\u30af\u30c1\u30f3\u5b89\u5168\u6027\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\uff08<strong>V-safe\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u30d8\u30eb\u30b9\u30c1\u30a7\u30c3\u30ab\u30fc<\/strong>\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3001<strong>V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea<\/strong>\u304a\u3088\u3073<strong>\u30ef\u30af\u30c1\u30f3\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\uff08VAERS\uff09<\/strong>\uff09\u3092\u4f7f\u7528\u3057\u3066\u3001\u598a\u5a66\u306b\u5bfe\u3059\u308bmRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u306b\u95a2\u3057\u3066\u3001\u4e88\u5099\u8abf\u67fb\u306e\u7d50\u679c\u3092\u5831\u544a\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"big\"><strong><span class=\"haiiro\">Methods<\/span><\/strong><\/span><br \/>\n<span class=\"big\"><strong>\u30e1\u30bd\u30c3\u30c9<\/strong><\/span><\/p>\n<hr>\n<p><strong><span class=\"haiiro\">MONITORING SYSTEMS AND COVERED POPULATIONS<\/span><\/strong><br \/>\n<strong>\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3068\u5bfe\u8c61\u96c6\u56e3<\/strong><\/p>\n<p><strong><em><span class=\"haiiro\">V-safe Surveillance System and Pregnancy Registry<\/span><\/em><\/strong><br \/>\n<strong><em>V-safe\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3068V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea<\/em><\/strong><\/p>\n<p><span class=\"haiiro\">V-safe is a new CDC smartphone-based active-surveillance system developed for the Covid-19 vaccination program; enrollment is voluntary.<\/span><br \/>\nV-safe\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30d7\u30ed\u30b0\u30e9\u30e0\u7528\u306b\u958b\u767a\u3055\u308c\u305fCDC\u306e\u65b0\u3057\u3044\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u30d9\u30fc\u30b9\u306e\u30a2\u30af\u30c6\u30a3\u30d6\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3067\u3001\u767b\u9332\u306f\u4efb\u610f\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">V-safe sends text messages to participants with weblinks to online surveys that assess for adverse reactions and health status during a postvaccination follow-up period.<\/span><br \/>\nV-safe\u306f\u3001\u8abf\u67fb\u7528\u306e\u30da\u30fc\u30b8\u306eWeb\u30ea\u30f3\u30af\u3092\u542b\u3080\u30c6\u30ad\u30b9\u30c8\u30e1\u30c3\u30bb\u30fc\u30b8\u3092\u53c2\u52a0\u8005\u306b\u9001\u4fe1\u3057\u307e\u3059\u3002\u3053\u306e\u8abf\u67fb\u306b\u3088\u308a\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u671f\u9593\u4e2d\u306e\u526f\u4f5c\u7528\u3068\u5065\u5eb7\u72b6\u614b\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Follow-up continues 12 months after the final dose of a Covid-19 vaccine.<\/span><br \/>\n\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u6700\u5f8c\u306e\u63a5\u7a2e\u5f8c12\u304b\u6708\u9593\u7d99\u7d9a\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">During the first week after vaccination with any dose of a Covid-19 vaccine, participants are prompted to report local and systemic signs and symptoms during daily surveys and rank them as mild, moderate, or severe;<\/span><br \/>\n\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\uff081\u5ea6\u76ee\u30012\u5ea6\u76ee\u306e\u3044\u305a\u308c\u3082\uff09\u306e\u6700\u521d\u306e\u9031\u306b\u3001\u53c2\u52a0\u8005\u306f\u3001\u6bce\u65e5\u3001\u5c40\u6240\u7684\u304a\u3088\u3073\u5168\u8eab\u7684\u306a\u5fb4\u5019\u3068\u75c7\u72b6\u3092\u8efd\u5ea6\u30fb\u4e2d\u5ea6\u30fb\u91cd\u5ea6\u306b\u30e9\u30f3\u30af\u4ed8\u3051\u3057\u3066\u5831\u544a\u3059\u308b\u3088\u3046\u306b\u4fc3\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">surveys at all time points assess for events of adverse health effects.<\/span><br \/>\n\u8abf\u67fb\u3067\u306f\u3001\u3059\u3079\u3066\u306e\u6642\u70b9\u306b\u304a\u3044\u3066\u3001\u5065\u5eb7\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u4e8b\u8c61\u3092\u8a55\u4fa1\u3057\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">If participants indicate that they required medical care at any time point, they are asked to complete a report to the VAERS through active telephone outreach.<\/span><br \/>\n\u53c2\u52a0\u8005\u306b\u533b\u7642\u306e\u30b1\u30a2\u304c\u5fc5\u8981\u3060\u3063\u305f\u3068\u5224\u65ad\u3055\u308c\u305f\u5834\u5408\u306f\u3001\u96fb\u8a71\u306b\u3088\u308b\u78ba\u8a8d\u304c\u7a4d\u6975\u7684\u306b\u884c\u308f\u308c\u3001VAERS\u306b\u5831\u544a\u3059\u308b\u3088\u3046\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">To identify persons who received one or both Covid-19 vaccine doses while pregnant or who became pregnant after Covid-19 vaccination, v-safe surveys include pregnancy questions for persons who do not report their sex as male.<\/span><br \/>\n\u598a\u5a20\u4e2d\u306b1\u56de\u307e\u305f\u306f2\u56de\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u3001\u307e\u305f\u306f\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u598a\u5a20\u3057\u305f\u4eba\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001V-safe\u8abf\u67fb\u306b\u306f\u3001\u6027\u5225\u3092\u7537\u6027\u3068\u3057\u3066\u5831\u544a\u3057\u3066\u3044\u306a\u3044\u4eba\u306b\u5bfe\u3059\u308b\u598a\u5a20\u306e\u8cea\u554f\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Persons who identify as pregnant are then contacted by telephone and, if they meet inclusion criteria, are offered enrollment in the v-safe pregnancy registry.<\/span><br \/>\n\u598a\u5a20\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u308b\u4eba\u306b\u306f\u96fb\u8a71\u306b\u3088\u308b\u9023\u7d61\u304c\u884c\u308f\u308c\u3001\u9078\u629e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3001V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u3078\u306e\u767b\u9332\u304c\u4fc3\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Eligible persons are those who received vaccination during pregnancy or in the periconception period (30 days before the last menstrual period through 14 days after) and are 18 years of age or older.<\/span><br \/>\nV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u3078\u306e\u767b\u9332\u5bfe\u8c61\u3068\u306a\u308b\u306e\u306f\u300118\u6b73\u4ee5\u4e0a\u3067\u3001\u598a\u5a20\u4e2d\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u304b\u3001\u53d7\u80ce\u524d\u5f8c\u306e\u671f\u9593\uff08\u6700\u5f8c\u306e\u6708\u7d4c\u306e30\u65e5\u524d\u304b\u308914\u65e5\u5f8c\u307e\u3067\uff09\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">For persons who choose to enroll, the pregnancy registry telephone-based survey collects detailed information about the participant, including medical and obstetric history, pregnancy complications, birth outcomes, and contact information for obstetric and pediatric health care providers to obtain medical records;<\/span><br \/>\nV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u767b\u9332\u3057\u305f\u4eba\u304b\u3089\u306f\u3001\u96fb\u8a71\u30d9\u30fc\u30b9\u306e\u8abf\u67fb\u306b\u3088\u308a\u3001\u8a73\u7d30\u306a\u60c5\u5831\u304c\u53ce\u96c6\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001\u75c5\u6b74\u304a\u3088\u3073\u7523\u79d1\u65e2\u5f80\u6b74\u3001\u598a\u5a20\u306e\u5408\u4f75\u75c7\u3001\u51fa\u7523\u306e\u8ee2\u5e30\u3001\u533b\u7642\u8a18\u9332\u306e\u53d6\u5f97\u306b\u5fc5\u8981\u306a\u7523\u79d1\u304a\u3088\u3073\u5c0f\u5150\u79d1\u306e\u9023\u7d61\u5148\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">infants are followed through the first 3 months of life.<\/span><br \/>\n\u4e73\u5150\u306f\u751f\u5f8c3\u30f6\u6708\u9593\u8ffd\u8de1\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Details about v-safe and v-safe pregnancy registry methods have been published previously.<\/span><br \/>\nV-safe\u304a\u3088\u3073V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u30e1\u30bd\u30c3\u30c9\u306e\u8a73\u7d30\u306f\u4ee5\u524d\u306b\u516c\u958b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><em><strong><span class=\"haiiro\">VAERS<\/span><\/strong><\/em><br \/>\n<em><strong>VAERS<\/strong><\/em><\/p>\n<p><span class=\"haiiro\">The VAERS is a national spontaneous-reporting (passive-surveillance) system established in 1990 that is administered by the CDC and the FDA.<\/span><br \/>\nVAERS\u306f\u30011990\u5e74\u306b\u8a2d\u7acb\u3055\u308c\u305f\u5168\u56fd\u7684\u306a\u81ea\u767a\u7684\u5831\u544a\uff08\u53d7\u52d5\u7684\u76e3\u8996\uff09\u30b7\u30b9\u30c6\u30e0\u3067\u3042\u308a\u3001CDC\u3068FDA\u306b\u3088\u3063\u3066\u7ba1\u7406\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Anyone can submit a report to the VAERS.<\/span><br \/>\n\u8ab0\u3067\u3082VAERS\u306b\u5831\u544a\u3092\u63d0\u51fa\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Health care providers are required to report certain adverse events after vaccination, including pregnancy-related complications resulting in hospitalization and congenital anomalies, under the conditions of the EUAs for Covid-19 vaccines;<\/span><br \/>\n\u533b\u7642\u63d0\u4f9b\u8005\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u7dca\u6025\u4f7f\u7528\u8a31\u53ef\uff08EUA\uff09\u306e\u6761\u4ef6\u306e\u4e0b\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u7279\u5b9a\u306e\u6709\u5bb3\u4e8b\u8c61\uff08\u5165\u9662\u3084\u5148\u5929\u6027\u7570\u5e38\u3092\u3082\u305f\u3089\u3059\u598a\u5a20\u95a2\u9023\u306e\u5408\u4f75\u75c7\u3092\u542b\u3080\uff09\u3092\u5831\u544a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">the CDC encourages reporting of any clinically significant maternal and infant adverse events.<\/span><br \/>\nCDC\u306f\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u3001\u6bcd\u4f53\u304a\u3088\u3073\u4e73\u5150\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u5831\u544a\u3092\u5968\u52b1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Signs and symptoms of adverse events are coded with the use of the Medical Dictionary for Regulatory Activities (MedDRA), version 23.1.<\/span><br \/>\n\u6709\u5bb3\u4e8b\u8c61\u306e\u5146\u5019\u3068\u75c7\u72b6\u306f\u3001\u300c<a href=\"https:\/\/www.meddra.org\/\" target=\"_blank\" rel=\"noopener\">\u533b\u85ac\u54c1\u898f\u5236\u7528\u8a9e\u96c6\uff08MedDRA\uff09<\/a>\u300d\u30d0\u30fc\u30b8\u30e7\u30f323.1\u3092\u4f7f\u7528\u3057\u3066\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">We used a pregnancy-status question in the VAERS form and a MedDRA code and text-string search to identify reports involving vaccination in pregnant persons.<\/span><br \/>\n\u6211\u3005\u306f\u3001VAERS\u306e\u598a\u5a20\u72b6\u6cc1\u306b\u95a2\u3059\u308b\u8cea\u554f\u30d5\u30a9\u30fc\u30e0\uff0fMedDRA\u306e\u898f\u5b9a\uff0f\u30c6\u30ad\u30b9\u30c8\u691c\u7d22\u3092\u4f7f\u7528\u3057\u3066\u3001\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u598a\u5a66\u306b\u95a2\u3059\u308b\u5831\u544a\u3092\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><strong><span class=\"haiiro\">OUTCOMES<\/span><\/strong><br \/>\n<strong>\u7d50\u679c<\/strong><\/p>\n<p><span class=\"haiiro\">V-safe outcomes included participant-reported local and systemic reactogenicity to the BNT162b2 (Pfizer\u2013BioNTech) vaccine and the mRNA-1273 (Moderna) vaccine on the day after vaccination among all pregnant persons 16 to 54 years of age and among nonpregnant women 16 to 54 years of age as a comparator.<\/span><br \/>\nV-safe\u306e\u7d50\u679c\u306b\u306f\u3001\u53c2\u52a0\u8005\u304c\u5831\u544a\u3057\u305f\u30ef\u30af\u30c1\u30f3\u306e\u5c40\u6240\u7684\u304a\u3088\u3073\u5168\u8eab\u7684\u306a\u526f\u53cd\u5fdc\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u526f\u53cd\u5fdc\u306f\u3001BNT162b2\uff08\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff09\u30ef\u30af\u30c1\u30f3\u307e\u305f\u306fmRNA-1273\uff08\u30e2\u30c7\u30eb\u30ca\uff09\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u7fcc\u65e5\u306b\u3042\u3089\u308f\u308c\u305f\u3082\u306e\u3067\u3059\u3002\u8abf\u67fb\u306e\u5bfe\u8c61\u8005\u306f\u300116\uff5e54\u6b73\u306e\u598a\u5a20\u4e2d\u306e\u5973\u6027\u3068\u3001\uff08\u6bd4\u8f03\u3068\u3057\u3066\uff0916\uff5e54\u6b73\u306e\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">For analysis of pregnancy outcomes in the v-safe pregnancy registry, data were restricted to completed pregnancies (i.e., live-born infant, spontaneous abortion, induced abortion, or stillbirth).<\/span><br \/>\nV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u3067\u306b\u3088\u308b\u598a\u5a20\u7d50\u679c\u306e\u5206\u6790\u306f\u3001\u598a\u5a20\u3092\u7d42\u3048\u305f\u4eba\uff08\u3059\u306a\u308f\u3061\u3001\u751f\u5150\u3001\u81ea\u7136\u6d41\u7523\u3001\u8a98\u767a\u6d41\u7523\u3001\u307e\u305f\u306f\u6b7b\u7523\uff09\u306b\u30c7\u30fc\u30bf\u304c\u9650\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Participant-reported pregnancy outcomes included pregnancy loss (spontaneous abortion and stillbirth) and neonatal outcomes (preterm birth, congenital anomalies, small size for gestational age, and neonatal death) (Table S1 in the Supplementary Appendix, available with the full text of this article at NEJM.org).<\/span><br \/>\n\u53c2\u52a0\u8005\u304b\u3089\u5831\u544a\u3055\u308c\u305f\u598a\u5a20\u306e\u8ee2\u5e30\u306b\u306f\u3001\u6d41\u7523\uff08\u81ea\u7136\u6d41\u7523\u3068\u6b7b\u7523\uff09\u304a\u3088\u3073\u65b0\u751f\u5150\u306e\u8ee2\u5e30\uff08\u65e9\u7523\u3001\u5148\u5929\u6027\u7570\u5e38\u3001\u5728\u80ce\u4e0d\u5f53\u904e\u5c0f\u3001\u304a\u3088\u3073\u65b0\u751f\u5150\u6b7b\u4ea1\uff09\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\uff08\u88dc\u8db3\u4ed8\u9332\u306e\u8868S1\u3002\u3053\u306e\u8a18\u4e8b\u306e\u5168\u6587\u3068\u3068\u3082\u306bNEJM.org\u3067\u5165\u624b\u53ef\u80fd\uff09\u3002<\/p>\n<p><span class=\"haiiro\">In the VAERS, outcomes included non\u2013pregnancy-specific adverse events and pregnancy- and neonatal-specific adverse events.<\/span><br \/>\nVAERS\u3067\u5831\u544a\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\u306b\u306f\u3001\u598a\u5a20\u306b\u56fa\u6709\u3067\u306f\u306a\u3044\u6709\u5bb3\u4e8b\u8c61\u3068\u3001\u598a\u5a20\u304a\u3088\u3073\u65b0\u751f\u5150\u306b\u56fa\u6709\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><strong><span class=\"haiiro\">STATISTICAL ANALYSIS<\/span><\/strong><br \/>\n<strong>\u7d71\u8a08\u5206\u6790<\/strong><\/p>\n<p><span class=\"haiiro\">Demographic information and pregnancy characteristics are described for both v-safe and VAERS participants.<\/span><br \/>\nV-safe\u3068VAERS\u306e\u4e21\u65b9\u306e\u53c2\u52a0\u8005\u306b\u3064\u3044\u3066\u3001\u4eba\u53e3\u7d71\u8a08\u60c5\u5831\u3068\u598a\u5a20\u306e\u7279\u5fb4\u304c\u8aac\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Descriptive analyses were performed with the use of v-safe survey data for persons who identified as pregnant through February 28, 2021 (35,691 persons);<\/span><br \/>\n\u8a18\u8ff0\u7684\u5206\u6790\u306f\u30012021\u5e742\u670828\u65e5\u307e\u3067\u306b\u598a\u5a20\u3057\u3066\u3044\u308b\u3068\u7279\u5b9a\u3055\u308c\u305f\u4eba\uff0835,691\u4eba\uff09\u306eV-safe\u8abf\u67fb\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">persons enrolled in the v-safe pregnancy registry who were vaccinated through February 28, 2021 (3958 persons);<\/span><br \/>\n2021\u5e742\u670828\u65e5\u307e\u3067\u306b\u4e88\u9632\u63a5\u7a2e\u3092\u53d7\u3051\u3066V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u767b\u9332\u3055\u308c\u305f\u306e\u306f3,958\u4eba\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">and VAERS reports involving pregnant women received through February 28, 2021 (221 persons).<\/span><br \/>\n\u307e\u305f\u30012021\u5e742\u670828\u65e5\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u305f\u598a\u5a66\u306b\u95a2\u3059\u308bVAERS\u30ec\u30dd\u30fc\u30c8\uff08221\u4eba\uff09\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Local and systemic reactogenicity was compared between persons who identified as pregnant and nonpregnant women.<\/span><br \/>\n\u598a\u5a20\u4e2d\u304a\u3088\u3073\u975e\u598a\u5a20\u4e2d\u306e\u5973\u6027\u3068\u7279\u5b9a\u3055\u308c\u305f\u4eba\u306e\u9593\u3067\u3001\u5c40\u6240\u7684\u304a\u3088\u3073\u5168\u8eab\u7684\u306a\u526f\u53cd\u5fdc\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Descriptive analyses were conducted with the use of SAS software, version 9.4 (SAS Institute).<\/span><br \/>\n\u8a18\u8ff0\u7684\u5206\u6790\u306f\u3001SAS\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u30d0\u30fc\u30b8\u30e7\u30f39.4\uff08SAS Institute\uff09\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">All activities were reviewed by the CDC and were conducted in accordance with applicable federal law and CDC policy.<\/span><br \/>\n\u3059\u3079\u3066\u306e\u6d3b\u52d5\u306fCDC\u306b\u3088\u3063\u3066\u30ec\u30d3\u30e5\u30fc\u3055\u308c\u3001\u9069\u7528\u3055\u308c\u308b\u9023\u90a6\u6cd5\u304a\u3088\u3073CDC\u30dd\u30ea\u30b7\u30fc\u306b\u5f93\u3063\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"big\"><strong><span class=\"haiiro\">Results<\/span><\/strong><\/span><br \/>\n<span class=\"big\"><strong>\u7d50\u679c<\/strong><\/span><\/p>\n<hr>\n<p><strong><span class=\"haiiro\">V-SAFE SURVEILLANCE: LOCAL AND SYSTEMIC REACTOGENICITY IN PREGNANT PERSONS<\/span><\/strong><br \/>\n<strong>V-safe \u306b\u3088\u308b\u89b3\u5bdf\uff1a\u598a\u5a20\u4e2d\u306e\u4eba\u306e\u5c40\u6240\u7684\u304a\u3088\u3073\u5168\u8eab\u7684\u306a\u526f\u53cd\u5fdc<\/strong><\/p>\n<p><span class=\"haiiro\">From December 14, 2020, to February 28, 2021, a total of 35,691 v-safe participants identified as pregnant.<\/span><br \/>\n2020\u5e7412\u670814\u65e5\u304b\u30892021\u5e742\u670828\u65e5\u306e\u9593\u306b\u3001\u5408\u8a0835,691\u4eba\u306eV-safe\u53c2\u52a0\u8005\u304c\u598a\u5a20\u3057\u3066\u3044\u308b\u3068\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Age distributions were similar among the participants who received the Pfizer\u2013BioNTech vaccine and those who received the Moderna vaccine, with the majority of the participants being 25 to 34 years of age (61.9% and 60.6% for each vaccine, respectively) and non-Hispanic White (76.2% and 75.4%, respectively);<\/span><br \/>\n\u5e74\u9f62\u5206\u5e03\u306f\u3001\u30d5\u30a1\u30a4\u30b6\u30fc\u306e\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u53c2\u52a0\u8005\u3068\u30e2\u30c7\u30eb\u30ca\u306e\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u53c2\u52a0\u8005\u306e\u9593\u3067\u985e\u4f3c\u3057\u3066\u304a\u308a\u3001\u53c2\u52a0\u8005\u306e\u5927\u591a\u6570\u306f25\uff5e34\u6b73\uff08\u5404\u30ef\u30af\u30c1\u30f3\u3067\u305d\u308c\u305e\u308c61.9\uff05\u306860.6\uff05\uff09\u3001\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u306e\u767d\u4eba\uff08\u305d\u308c\u305e\u308c76.2\uff05\u306875.4\uff05\uff09\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">most participants (85.8% and 87.4%, respectively) reported being pregnant at the time of vaccination (Table 1).<\/span><br \/>\n\u307b\u3068\u3093\u3069\u306e\u53c2\u52a0\u8005\uff08\u305d\u308c\u305e\u308c85.8\uff05\u306887.4\uff05\uff09\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6642\u306b\u598a\u5a20\u3057\u3066\u3044\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u88681\uff09\u3002<\/p>\n<div class=\"sng-box box6\">\n<p><span class=\"haiiro\">Table 1. Characteristics of Persons Who Identified as Pregnant in the V-safe Surveillance System and Received an mRNA Covid-19 Vaccine<\/span><br \/>\n\u88681\u3000V-safe\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3067\u598a\u5a20\u3057\u3066\u3044\u308b\u3068\u7279\u5b9a\u3055\u308c\u3001mRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u306e\u7279\u5fb4<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6094 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_1.png\" alt=\"\" width=\"787\" height=\"714\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_1.png 787w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_1-300x272.png 300w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_1-768x697.png 768w\" sizes=\"auto, (max-width: 787px) 100vw, 787px\"><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"haiiro\">*&nbsp;Shown are the characteristics of v-safe participants 16 to 54 years of age who identified as pregnant and who received a messenger RNA (mRNA) coronavirus disease 2019 (Covid-19) vaccine \u2014 BNT162b2 (Pfizer\u2013BioNTech) or mRNA-1273 (Moderna) \u2014 from December 14, 2020, to February 28, 2021. Percentages may not total 100 because of rounding.<br \/>\n<\/span>* 2020\u5e7412\u670814\u65e5\uff5e2021\u5e742\u670828\u65e5\u307e\u3067\u306b\u3001\u598a\u5a66\u3068\u7279\u5b9a\u3055\u308c\u3001mRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\uff08 BNT162b2\uff3b\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff3d\u307e\u305f\u306fmRNA-1273\uff3b\u30e2\u30c7\u30eb\u30ca\uff3d\uff09\u3092\u63a5\u7a2e\u3057\u305f\u3001V-safe\u53c2\u52a0\u8005\uff0816\uff5e54\u6b73\uff09\u306e\u7279\u5fb4 \u3002\u56db\u6368\u4e94\u5165\u306b\u3088\u308a\u3001\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8\u306e\u5408\u8a08\u304c100\u306b\u306a\u3089\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"haiiro\">\u2020 Race and ethnic group were reported by the participants. Questions about race and ethnic group were added to v-safe after launch of the platform; not all pregnancies had recorded race and ethnic group at the time of data analysis. Therefore, data on race and ethnic group were missing for 22.8% of the total number of participants who identified as pregnant (4932 participants receiving the Pfizer\u2013BioNTech vaccine and 3207 receiving the Moderna vaccine).<br \/>\n<\/span>\u2020 \u53c2\u52a0\u8005\u304b\u3089\u4eba\u7a2e\u3084\u6c11\u65cf\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e\u7acb\u3061\u4e0a\u3052\u5f8c\u3001\u4eba\u7a2e\u3084\u6c11\u65cf\u306b\u95a2\u3059\u308b\u8cea\u554f\u304cV-safe\u306b\u8ffd\u52a0\u3055\u308c\u307e\u3057\u305f\u3002\u30c7\u30fc\u30bf\u5206\u6790\u306e\u6642\u70b9\u3067\u3001\u3059\u3079\u3066\u306e\u598a\u5a66\u306e\u4eba\u7a2e\u304a\u3088\u3073\u6c11\u65cf\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u598a\u5a20\u3057\u3066\u3044\u308b\u3068\u7279\u5b9a\u3055\u308c\u305f\u53c2\u52a0\u8005\u306e22.8\uff05\u306f\u4eba\u7a2e\u304a\u3088\u3073\u6c11\u65cf\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u304c\u6b20\u843d\u3057\u3066\u3044\u307e\u3057\u305f\uff084,932\u4eba\u306e\u53c2\u52a0\u8005\u304c\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\u306e\u30ef\u30af\u30c1\u30f3\u30013,207\u4eba\u306e\u53c2\u52a0\u8005\u304c\u30e2\u30c7\u30eb\u30ca\u306e\u30ef\u30af\u30c1\u30f3\u3067\u3057\u305f\uff09\u3002<\/p>\n<\/div>\n<p><span class=\"haiiro\">Solicited reports of injection-site pain, fatigue, headache, and myalgia were the most frequent local and systemic reactions after either dose for both vaccines (Table 2) and were reported more frequently after dose 2 for both vaccines.<\/span><br \/>\n\u53c2\u52a0\u8005\u304b\u3089\u306e\u5831\u544a\u306b\u3088\u308b\u3068\u3001\u4e21\u65b9\u306e\u30ef\u30af\u30c1\u30f3\u3067\u6700\u3082\u591a\u3044\u5c40\u6240\u304a\u3088\u3073\u5168\u8eab\u53cd\u5fdc\u306f\u3001\u6ce8\u5c04\u90e8\u4f4d\u306e\u75db\u307f\u3001\u5026\u6020\u611f\u3001\u982d\u75db\u3001\u304a\u3088\u3073\u7b4b\u8089\u75db\u3067\u3057\u305f\uff08\u88682\uff09\u3002\u305d\u3057\u3066\u3001\u3044\u305a\u308c\u306e\u30ef\u30af\u30c1\u30f3\u306e\u5834\u5408\u3067\u3082\u30012\u56de\u76ee\u306e\u63a5\u7a2e\u5f8c\u306b\u3088\u308a\u591a\u304f\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<div class=\"sng-box box6\">\n<p><span class=\"haiiro\">Table 2. Frequency of Local and Systemic Reactions Reported on the Day after mRNA Covid-19 Vaccination in Pregnant Persons.<\/span><br \/>\n\u88682\u3000\u598a\u5a20\u4e2d\u306e\u4eba\u304cmRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u7fcc\u65e5\u306b\u5831\u544a\u3057\u305f\u5c40\u6240\u304a\u3088\u3073\u5168\u8eab\u53cd\u5fdc\u306e\u983b\u5ea6<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6093 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_2.png\" alt=\"\" width=\"826\" height=\"591\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_2.png 826w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_2-300x215.png 300w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_2-768x550.png 768w\" sizes=\"auto, (max-width: 826px) 100vw, 826px\"><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"haiiro\"><label>*&nbsp;<\/label>Shown are solicited reactions in v-safe participants 16 to 54 years of age who identified as pregnant and who received an mRNA Covid-19 vaccine (BNT162b2 [Pfizer\u2013BioNTech] or mRNA-1273 [Moderna]) from December 14, 2020, to February 28, 2021.<\/span><br \/>\n* 2020\u5e7412\u670814\u65e5\uff5e2021\u5e742\u670828\u65e5\u306b\u3001\u598a\u5a66\u3068\u7279\u5b9a\u3055\u308c\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\uff08BNT162b2\uff3b\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff3d\u307e\u305f\u306fmRNA-1273\uff3b\u30e2\u30c7\u30eb\u30ca\uff3d\uff09\u3092\u63a5\u7a2e\u3057\u305f16\u301c54\u6b73\u306eV-safe\u53c2\u52a0\u8005\u306e\u526f\u53cd\u5fdc<\/p>\n<\/div>\n<p><span class=\"haiiro\">Participant-measured temperature at or above 38\u00b0C was reported by less than 1% of the participants on day 1 after dose 1 and by 8.0% after dose 2 for both vaccines.<\/span><br \/>\n\u4e21\u65b9\u306e\u30ef\u30af\u30c1\u30f3\u3067\u3001\u63a5\u7a2e\u306e\u7fcc\u65e5\u306b\u4f53\u6e29\u304c38\u00b0C\u4ee5\u4e0a\uff08\u53c2\u52a0\u8005\u81ea\u8eab\u306b\u3088\u308b\u6e2c\u5b9a\uff09\u306b\u306a\u3063\u305f\u53c2\u52a0\u8005\u306e\u5272\u5408\u306f\u30011\u56de\u76ee\u306e\u63a5\u7a2e\u5f8c\u306f1\uff05\u672a\u6e80\u30012\u56de\u76ee\u306e\u63a5\u7a2e\u5f8c\u306f8.0\uff05\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">These patterns of reporting, with respect to both most frequently reported solicited reactions and the higher reporting of reactogenicity after dose 2, were similar to patterns observed among nonpregnant women (Figure 1).<\/span><br \/>\n\u3053\u308c\u3089\u306e\u5831\u544a\u3055\u308c\u305f\u30d1\u30bf\u30fc\u30f3\uff08\u6700\u3082\u591a\u304b\u3063\u305f\u526f\u53cd\u5fdc\u304a\u3088\u30732\u56de\u76ee\u63a5\u7a2e\u5f8c\u306b\uff081\u56de\u76ee\u3088\u308a\u3082\uff09\u3088\u308a\u591a\u304f\u5831\u544a\u3055\u308c\u305f\u526f\u53cd\u5fdc\uff09\u306f\u3001\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\u3067\u89b3\u5bdf\u3055\u308c\u305f\u30d1\u30bf\u30fc\u30f3\u3068\u985e\u4f3c\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f31\uff09\u3002<\/p>\n<div class=\"sng-box box6\">\n<p><span class=\"haiiro\">Figure 1. Most Frequent Local and Systemic Reactions Reported in the V-safe Surveillance System on the Day after mRNA Covid-19 Vaccination.<\/span><br \/>\n\u56f31\u3000mRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u7fcc\u65e5\u306bV-safe\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u306b\u5831\u544a\u3055\u308c\u305f\u6700\u3082\u591a\u3044\u5c40\u6240\u304a\u3088\u3073\u5168\u8eab\u306e\u53cd\u5fdc<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6092\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_3.png\" alt=\"\" width=\"900\" height=\"488\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_3.png 900w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_3-300x163.png 300w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_3-768x416.png 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\"><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"haiiro\">Shown are solicited reactions in pregnant persons and nonpregnant women 16 to 54 years of age who received a messenger RNA (mRNA) coronavirus disease 2019 (Covid-19) vaccine \u2014 BNT162b2 (Pfizer\u2013BioNTech) or mRNA-1273 (Moderna) \u2014 from December 14, 2020, to February 28, 2021. The percentage of respondents was calculated among those who completed a day 1 survey, with the top events shown of injection-site pain (pain), fatigue or tiredness (fatigue), headache, muscle or body aches (myalgia), chills, and fever or felt feverish (fever).<\/span><br \/>\n2020\u5e7412\u670814\u65e5\uff5e2021\u5e742\u670828\u65e5\u306b\u3001mRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\uff08BNT162b2\uff3b\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff3d\u307e\u305f\u306fmRNA-1273\uff3b\u30e2\u30c7\u30eb\u30ca\uff3d\uff09\u3092\u63a5\u7a2e\u3057\u305f\u3001\u598a\u5a20\u3057\u3066\u3044\u308b\u4eba\u3068\u598a\u5a20\u3057\u3066\u306a\u3044\u4eba\uff0816\u301c54\u6b73\uff09\u306e\u526f\u53cd\u5fdc\u3002\u56de\u7b54\u8005\u306e\u5272\u5408\u306f\u30011\u65e5\u76ee\u306e\u8abf\u67fb\u306e\u56de\u7b54\u304b\u3089\u4f5c\u6210\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u3082\u591a\u304b\u3063\u305f\u306e\u306f\u6ce8\u5c04\u90e8\u4f4d\u306e\u75db\u307f\uff08Pain\uff09\u3001\u7d9a\u3044\u3066\u75b2\u52b4\u307e\u305f\u306f\u5026\u6020\u611f\uff08Fatigue\uff09\u3001\u982d\u75db\uff08Headache\uff09\u3001\u7b4b\u8089\u307e\u305f\u306f\u4f53\u306e\u75db\u307f\uff08Myalgia\uff09\u3001\u5bd2\u6c17\uff08Chills\uff09\u3001\u767a\u71b1\u307e\u305f\u306f\u307b\u3066\u308a\uff08Fever\uff09\u3067\u3057\u305f\u3002<\/p>\n<\/div>\n<p><span class=\"haiiro\">Small differences in reporting frequency between pregnant persons and nonpregnant women were observed for specific reactions (injection-site pain was reported more frequently among pregnant persons, and other systemic reactions were reported more frequently among nonpregnant women), but the overall reactogenicity profile was similar.<\/span><br \/>\n\u598a\u5a20\u4e2d\u306e\u4eba\u3068\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\u306e\u9593\u306b\u304a\u3044\u3066\u3001\u7279\u5b9a\u306e\u526f\u53cd\u5fdc\u306e\u5831\u544a\u983b\u5ea6\u306b\u308f\u305a\u304b\u306a\u9055\u3044\u304c\u3042\u308a\u307e\u3057\u305f\uff08\u6ce8\u5c04\u90e8\u4f4d\u306e\u75db\u307f\u306f\u598a\u5a20\u4e2d\u306e\u4eba\u306e\u9593\u3067\u3088\u308a\u983b\u7e41\u306b\u5831\u544a\u3055\u308c\u3001\u4ed6\u306e\u5168\u8eab\u53cd\u5fdc\u306f\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\u306e\u9593\u3067\u3088\u308a\u983b\u7e41\u306b\u5831\u544a\u3055\u308c\u307e\u3057\u305f\uff09\u304c\u3001\u526f\u53cd\u5fdc\u306e\u5168\u4f53\u7684\u306a\u30c7\u30fc\u30bf\u306f\u985e\u4f3c\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Pregnant persons did not report having severe reactions more frequently than nonpregnant women, except for nausea and vomiting, which were reported slightly more frequently only after dose 2 (Table S3).<\/span><br \/>\n\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u5973\u6027\u3068\u6bd4\u8f03\u3057\u3066\u30012\u56de\u76ee\u63a5\u7a2e\u5f8c\u306e\u60aa\u5fc3\u3068\u5614\u5410\u304c\u598a\u5a20\u4e2d\u306e\u4eba\u304b\u3089\u308f\u305a\u304b\u306b\u591a\u304f\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u91cd\u7be4\u306a\u526f\u53cd\u5fdc\u306e\u5831\u544a\u6570\u304c\u591a\u3044\u3068\u3044\u3046\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u8868S3\uff09\u3002<\/p>\n<p><strong><span class=\"haiiro\">V-SAFE PREGNANCY REGISTRY: PREGNANCY OUTCOMES AND NEONATAL OUTCOMES<\/span><\/strong><br \/>\n<strong>V-safe \u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\uff1a\u598a\u5a20\u8ee2\u5e30\u3068\u65b0\u751f\u5150\u8ee2\u5e30<\/strong><\/p>\n<p><span class=\"haiiro\">As of March 30, 2021, the v-safe pregnancy registry call center attempted to contact 5230 persons who were vaccinated through February 28, 2021, and who identified during a v-safe survey as pregnant at or shortly after Covid-19 vaccination.<\/span><br \/>\n2021\u5e743\u670830\u65e5\u306e\u6642\u70b9\u3067\u3001V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u30b3\u30fc\u30eb\u30bb\u30f3\u30bf\u30fc\u306f\u30012021\u5e742\u670828\u65e5\u307e\u3067\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u3066\u3044\u305f5,230\u4eba\uff08\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6642\u306b\u598a\u5a20\u3057\u3066\u3044\u305f\u304b\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u3059\u3050\u5f8c\u3067V-safe\u8abf\u67fb\u4e2d\u306b\u598a\u5a20\u3057\u305f\u4eba\uff09\u306b\u9023\u7d61\u3092\u8a66\u307f\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Of these, 912 were unreachable, 86 declined to participate, and 274 did not meet inclusion criteria (e.g., were never pregnant, were pregnant but received vaccination more than 30 days before the last menstrual period, or did not provide enough information to determine eligibility).<\/span><br \/>\n\u3053\u308c\u3089\u306e\u3046\u3061\u3001912\u4eba\u3068\u306f\u9023\u7d61\u304c\u3064\u304b\u305a\u300186\u4eba\u306fV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u3078\u306e\u53c2\u52a0\u3092\u62d2\u5426\u3057\u3001274\u4eba\u306f\u767b\u9332\u57fa\u6e96\u3092\u6e80\u305f\u3057\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u305f\u3068\u3048\u3070\u3001\u598a\u5a20\u3067\u306f\u306a\u304b\u3063\u305f\uff0f\u598a\u5a20\u3057\u3066\u3044\u305f\u304c\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u306e\u304c\u6700\u5f8c\u306e\u6708\u7d4c\u306e30\u65e5\u4ee5\u4e0a\u524d\u3060\u3063\u305f\uff0f\u767b\u9332\u57fa\u6e96\u3092\u5224\u5b9a\u3059\u308b\u305f\u3081\u306e\u5341\u5206\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u306a\u304b\u3063\u305f\u7b49\uff09\u3002<\/p>\n<p><span class=\"haiiro\">The registry enrolled 3958 participants with vaccination from December 14, 2020, to February 28, 2021, of whom 3719 (94.0%) identified as health care personnel.<\/span><br \/>\n2020\u5e7412\u670814\u65e5\u304b\u30892021\u5e742\u670828\u65e5\u307e\u3067\u306e\u9593\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f3,958\u4eba\u304cV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u767b\u9332\u3055\u308c\u307e\u3057\u305f\uff08\u305d\u306e\u3046\u30613,719\u4eba\uff3b94.0\uff05\uff3d\u304c\u533b\u7642\u5f93\u4e8b\u8005\u3067\u3057\u305f\uff09\u3002<\/p>\n<p><span class=\"haiiro\">Among enrolled participants, most were 25 to 44 years of age (98.8%), non-Hispanic White (79.0%), and, at the time of interview, did not report a Covid-19 diagnosis during pregnancy (97.6%) (Table 3).<\/span><br \/>\n\u767b\u9332\u3055\u308c\u305f\u53c2\u52a0\u8005\u306e\u307b\u3068\u3093\u3069\u306f25\uff5e44\u6b73\uff0898.8\uff05\uff09\u306e\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u767d\u4eba\uff0879.0\uff05\uff09\u3067\u3042\u308a\u3001\u805e\u304d\u53d6\u308a\u8abf\u67fb\u306e\u6642\u70b9\u3067\u306f\u3001\u307b\u3068\u3093\u3069\u306f\u598a\u5a20\u4e2d\u306b\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u611f\u67d3\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff0897.6\uff05\uff09\uff08\u88683\uff09\u3002<\/p>\n<div class=\"sng-box box6\">\n<p><span class=\"haiiro\">Table 3. Characteristics of V-safe Pregnancy Registry Participants.<\/span><br \/>\n\u88683\u3000V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u53c2\u52a0\u8005\u306e\u7279\u5fb4<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6095 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_4.png\" alt=\"\" width=\"795\" height=\"889\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_4.png 795w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_4-268x300.png 268w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_4-768x859.png 768w\" sizes=\"auto, (max-width: 795px) 100vw, 795px\"><\/a><\/p>\n<p>&nbsp;<\/p>\n<div class=\"m-data-table__foot\">\n<div id=\"t3fn1\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>*&nbsp;<\/label>Shown are registry participants who received an mRNA Covid-19 vaccine (BNT162b2 [Pfizer\u2013BioNTech] or mRNA-1273 [Moderna]) from December 14, 2020, to February 28, 2021. Percentages may not total 100 because of rounding.<\/span><br \/>\n<label>*&nbsp;<\/label>2020\u5e7412\u670814\u65e5\uff5e2021\u5e742\u670828\u65e5\u306b\u3001mRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\uff08BNT162b2\uff3b\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff3d\u307e\u305f\u306fmRNA-1273\uff3b\u30e2\u30c7\u30eb\u30ca\uff3d\uff09\u3092\u63a5\u7a2e\u3057\u305fV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u53c2\u52a0\u8005\u3002\u56db\u6368\u4e94\u5165\u306b\u3088\u308a\u3001\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8\u306e\u5408\u8a08\u304c100\u306b\u306a\u3089\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>\u2020&nbsp;<\/label>The v-safe pregnancy registry is only enrolling pregnant persons 18 years of age or older; at the time of this analysis, no participants were younger than 20 years of age.<\/span><\/p>\n<p><label>\u2020 <\/label>V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306f\u300118\u6b73\u4ee5\u4e0a\u306e\u598a\u5a20\u8005\u306e\u307f\u3092\u767b\u9332\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5206\u6790\u306e\u6642\u70b9\u3067\u306f\u300120\u6b73\u672a\u6e80\u306e\u53c2\u52a0\u8005\u306f\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"m-data-table__foot\">\n<div id=\"t3fn2\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>\u2021&nbsp;<\/label>Race and ethnic group were reported by the participants.<\/span><\/p>\n<div class=\"m-data-table__foot\">\n<div id=\"t3fn3\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><label>\u2021&nbsp;<\/label>\u53c2\u52a0\u8005\u304b\u3089\u4eba\u7a2e\u3084\u6c11\u65cf\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><span class=\"haiiro\">Receipt of a first dose of vaccine meeting registry-eligibility criteria was reported by 92 participants (2.3%) during the periconception period, by 1132 (28.6%) in the first trimester of pregnancy, by 1714 (43.3%) in the second trimester, and by 1019 (25.7%) in the third trimester (1 participant was missing information to determine the timing of vaccination) (Table 3).<\/span><br \/>\nV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u767b\u9332\u57fa\u6e96\u3092\u6e80\u305f\u30591\u56de\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u304c\u63a5\u7a2e\u3055\u308c\u305f\u30bf\u30a4\u30df\u30f3\u30b0\u306f\u3001\u53d7\u80ce\u524d\u5f8c\u306e\u671f\u9593\u304c92\u4eba\uff082.3\uff05\uff09\u3001\u598a\u5a20\u306e\u7b2c1\u671f\u304c1,132\u4eba\uff0828.6\uff05\uff09\u3001\u7b2c2\u671f\u304c1,714\uff0843.3\uff05\uff09\u3001\u305d\u3057\u3066\u7b2c3\u671f\u304c1,019\u4eba\uff0825.7\uff05\uff09\u3067\u3057\u305f\uff081\u4eba\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u304c\u4e0d\u660e\uff09\uff08\u88683\uff09\u3002<\/p>\n<p><span class=\"haiiro\">Among 1040 participants (91.9%) who received a vaccine in the first trimester and 1700 (99.2%) who received a vaccine in the second trimester, initial data had been collected and follow-up scheduled at designated time points approximately 10 to 12 weeks apart;<\/span><br \/>\n\u7b2c1\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\uff081,132\u4eba\u306e\u3046\u3061\uff091,040\u4eba\uff0891.9\uff05\uff09\u3068\u7b2c2\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\uff081,714\u4eba\u306e\u3046\u3061\uff091,700\u4eba\uff0899.2\uff05\uff09\u306e\u4e2d\u304b\u3089\u521d\u671f\u30c7\u30fc\u30bf\u304c\u53ce\u96c6\u3055\u308c\u3001\u7d0410\uff5e12\u9031\u9593\u306e\u9593\u9694\u3092\u7f6e\u3044\u3066\u7279\u5b9a\u306e\u6642\u70b9\u3067\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">limited follow-up calls had been made at the time of this analysis.<\/span><br \/>\n\u3053\u306e\u5206\u6790\u306e\u6642\u70b9\u3067\u306f\u3001\u96fb\u8a71\u306b\u3088\u308b\u9650\u5b9a\u7684\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Among 827 participants who had a completed pregnancy, the pregnancy resulted in a live birth in 712 (86.1%), in a spontaneous abortion in 104 (12.6%), in stillbirth in 1 (0.1%), and in other outcomes (induced abortion and ectopic pregnancy) in 10 (1.2%).<\/span><br \/>\n\u598a\u5a20\u3092\u7d42\u3048\u305f827\u4eba\u306e\u3046\u3061\u3001\u51fa\u7523\u304c712\u4eba\uff0886.1%\uff09\u3001\u81ea\u7136\u6d41\u7523\u304c104\u4eba\uff0812.6%\uff09\u3001\u6b7b\u7523\u304c1\u4eba\uff080.1%\uff09\u3001\u305d\u306e\u4ed6\u304c10\u4eba\uff08\u4e2d\u7d76\u3001\u5b50\u5bae\u5916\u598a\u5a20\u306a\u30691.2%\uff09\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">A total of 96 of 104 spontaneous abortions (92.3%) occurred before 13 weeks of gestation (Table 4), and 700 of 712 pregnancies that resulted in a live birth (98.3%) were among persons who received their first eligible vaccine dose in the third trimester.<\/span><br \/>\n104\u4eba\u306e\u81ea\u7136\u6d41\u7523\u306e\u3046\u306196\u4ef6\uff0892.3%\uff09\u304c\u598a\u5a2013\u9031\u76ee\u3088\u308a\u524d\u306b\u8d77\u304d\u307e\u3057\u305f\uff08\u88684\uff09\u3002\u51fa\u7523\u3057\u305f712\u4eba\u306e\u3046\u3061700\u4eba\uff0898.3%\uff09\u306f\u3001\u7b2c\uff13\u671f\u306b\u6700\u521d\u306e\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<div class=\"sng-box box6\">\n<p><span class=\"haiiro\">Table 4. Pregnancy Loss and Neonatal Outcomes in Published Studies and V-safe Pregnancy Registry Participants.<\/span><br \/>\n\u88684\u3000\u6d41\u7523\u30fb\u65b0\u751f\u5150\u8ee2\u5e30\u306b\u95a2\u3059\u308b\u904e\u53bb\u306e\u8abf\u67fb\u30c7\u30fc\u30bf\u3068V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u30c7\u30fc\u30bf\u306e\u6bd4\u8f03<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6091 bigshadow\" src=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_5.png\" alt=\"\" width=\"743\" height=\"345\" srcset=\"https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_5.png 743w, https:\/\/www.hoe2021.com\/wp-content\/uploads\/2021\/07\/2021-07-22_5-300x139.png 300w\" sizes=\"auto, (max-width: 743px) 100vw, 743px\"><\/a><\/p>\n<p>&nbsp;<\/p>\n<div class=\"m-data-table__foot\">\n<div id=\"t4fn1\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>*&nbsp;<\/label>The populations from which these rates are derived are not matched to the current study population for age, race and ethnic group, or other demographic and clinical factors.<\/span><br \/>\n* \u3053\u308c\u3089\uff08\u904e\u53bb\u306e\u8abf\u67fb\u30c7\u30fc\u30bf\uff09\u306e\u7387\u304c\u5c0e\u304d\u51fa\u3055\u308c\u305f\u96c6\u56e3\u306f\u3001\u5e74\u9f62\uff0f\u4eba\u7a2e\uff0f\u6c11\u65cf\uff0f\u305d\u306e\u4ed6\u306e\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u304a\u3088\u3073\u81e8\u5e8a\u7684\u8981\u56e0\u306b\u304a\u3044\u3066\u3001\u73fe\u5728\u306e\u8abf\u67fb\u5bfe\u8c61\u306e\u96c6\u56e3\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"m-data-table__foot\">\n<div id=\"t4fn2\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>\u2020&nbsp;<\/label>Data on pregnancy loss are based on 827 participants in the v-safe pregnancy registry who received an mRNA Covid-19 vaccine (BNT162b2 [Pfizer\u2013BioNTech] or mRNA-1273 [Moderna]) from December 14, 2020, to February 28, 2021, and who reported a completed pregnancy. A total of 700 participants (84.6%) received their first eligible dose in the third trimester. Data on neonatal outcomes are based on 724 live-born infants, including 12 sets of multiples.<\/span><br \/>\n\u2020 \u598a\u5a20\u640d\u5931\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u30012020\u5e7412\u670814\u65e5\uff5e2021\u5e742\u670828\u65e5\u306e\u9593\u306b mRNA \u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\uff08BNT162b2\uff3b\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d3\u30aa\u30f3\u30c6\u30c3\u30af\uff3d\u307e\u305f\u306fmRNA-1273\uff3b\u30e2\u30c7\u30eb\u30ca\uff3d\uff09\u3092\u63a5\u7a2e\u3057\u3001V-safe\u306b\u598a\u5a20\u767b\u9332\u3057\u3001\u598a\u5a20\u3092\u7d42\u3048\u305f827\u4eba\u306e\u53c2\u52a0\u8005\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3046\u3061700\u4eba\u306e\u53c2\u52a0\u8005\uff0884.6\uff05\uff09\u304c\u598a\u5a20\u306e\u7b2c3\u671f\u306b\u6700\u521d\u306e\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u307e\u3057\u305f\u3002\u65b0\u751f\u5150\u306e\u8ee2\u5e30\uff08\u75c7\u72b6\u30fb\u72b6\u614b\u306e\u7d4c\u904e\u3084\u7d50\u679c\uff09\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u3001724\u4eba\u306e\u751f\u7523\u5150\uff0812\u7d44\u306e\u591a\u80ce\u5150\u3092\u542b\u3080\uff09\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"m-data-table__foot\">\n<div id=\"t4fn3\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>\u2021&nbsp;<\/label>A total of 96 of 104 spontaneous abortions (92.3%) occurred before 13 weeks of gestation.<\/span><br \/>\n\u2021 104\u4ef6\u4e2d96\u4ef6\u306e\u81ea\u7136\u6d41\u7523\uff0892.3\uff05\uff09\u304c\u598a\u5a2013\u9031\u524d\u306b\u767a\u751f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"m-data-table__foot\">\n<div id=\"t4fn4\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>\u00a7&nbsp;<\/label>The denominator includes live-born infants and stillbirths.<\/span><br \/>\n\u00a7&nbsp;\u5206\u6bcd\u306b\u306f\u751f\u5150\u3068\u6b7b\u7523\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"m-data-table__foot\">\n<div id=\"t4fn5\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>\u00b6&nbsp;<\/label>The denominator includes only participants vaccinated before 37 weeks of gestation.<\/span><br \/>\n\u00b6 \u5206\u6bcd\u306b\u306f\u598a\u5a2037\u9031\u3088\u308a\u524d\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u53c2\u52a0\u8005\u306e\u307f\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"m-data-table__foot\">\n<div id=\"t4fn6\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><label>\u2016&nbsp;<\/label><span class=\"haiiro\">Small size for gestational age indicates a birthweight below the 10th percentile for gestational age and infant sex according to INTERGROWTH-21<sup>st<\/sup>&nbsp;growth standards (<a class=\"ext-link\" href=\"http:\/\/intergrowth21.ndog.ox.ac.uk\/\" target=\"_blank\" rel=\"noopener\">http:\/\/intergrowth21.ndog.ox.ac.uk<span class=\"sr-only\">. opens in new tab<\/span><\/a>). These standards draw from an international sample including both low-income and high-income countries but exclude children with coexisting conditions and malnutrition. They can be used as a standard for healthy children growing under optimal conditions.<\/span><br \/>\n\u2016 \u5728\u80ce\u4e0d\u5f53\u904e\u5c0f\u3068\u306f\u3001INTERGROWTH-21<sup>st<\/sup>&nbsp;Growth Standards\uff08<a class=\"ext-link\" href=\"http:\/\/intergrowth21.ndog.ox.ac.uk\/\" target=\"_blank\" rel=\"noopener\">http:\/\/intergrowth21.ndog.ox.ac.uk\uff09<\/a>\u306e\u57fa\u6e96\u306b\u5f93\u3063\u3066\u3001\u5728\u80ce\u9031\u6570\u3068\u4e73\u5150\u306e\u6027\u5225\u304b\u3089\u8a08\u7b97\u3055\u308c\u308b\u300110<a href=\"https:\/\/www.google.com\/search?q=%E3%83%91%E3%83%BC%E3%82%BB%E3%83%B3%E3%82%BF%E3%82%A4%E3%83%AB&amp;oq=%E3%83%91%E3%83%BC%E3%82%BB%E3%83%B3%E3%82%BF%E3%82%A4%E3%83%AB&amp;aqs=chrome..69i57j0l8.343j0j4&amp;sourceid=chrome&amp;ie=UTF-8\" target=\"_blank\" rel=\"noopener\">\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb<\/a>\u672a\u6e80\u306e\u51fa\u751f\u4f53\u91cd\u3092\u793a\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u57fa\u6e96\u306f\u3001\u4f4e\u6240\u5f97\u56fd\u3068\u9ad8\u6240\u5f97\u56fd\u306e\u4e21\u65b9\u3092\u542b\u3080\u56fd\u969b\u7684\u306a\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u5f97\u3089\u308c\u305f\u3082\u306e\u3067\u3059\u304c\u3001\u4f75\u5b58\u75be\u60a3\u3092\u6301\u3064\u5b50\u4f9b\u3068\u6804\u990a\u5931\u8abf\u306e\u5b50\u4f9b\u306f\u9664\u5916\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u3053\u308c\u3089\u306e\u57fa\u6e96\u306f\u3001\u6700\u9069\u306a\u6761\u4ef6\u4e0b\u3067\u6210\u9577\u3059\u308b\u5065\u5eb7\u306a\u5b50\u4f9b\u306e\u305f\u3081\u306e\u57fa\u6e96\u3068\u3057\u3066\u4f7f\u7528\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"m-data-table__foot\">\n<div id=\"t4fn7\">\n<div class=\"f-body--xs\">\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>**&nbsp;<\/label>Values include only major congenital anomalies in accordance with the Metropolitan Atlanta Congenital Defects Program 6-Digit Code Defect List (<a class=\"ext-link\" href=\"https:\/\/www.cdc.gov\/ncbddd\/birthdefects\/macdp.html\" target=\"_blank\" rel=\"noopener\">www.cdc.gov\/ncbddd\/birthdefects\/macdp.html<span class=\"sr-only\">. opens in new tab<\/span><\/a>); all pregnancies with major congenital anomalies were exposed to Covid-19 vaccines only in the third trimester of pregnancy (i.e., well after the period of organogenesis).<\/span><br \/>\n<label>** <\/label>\u5024\u306b\u306f\u3001Metropolitan Atlanta Congenital Defects Program 6-Digit Code Defect List\uff08<a class=\"ext-link\" href=\"https:\/\/www.cdc.gov\/ncbddd\/birthdefects\/macdp.html\" target=\"_blank\" rel=\"noopener\">www.cdc.gov\/ncbddd\/birthdefects\/macdp.html\uff09<\/a>\u306b\u5f93\u3063\u3066\u3001\u4e3b\u8981\u306a\u5148\u5929\u6027\u7570\u5e38\u306e\u307f\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u4e3b\u8981\u306a\u5148\u5929\u6027\u7570\u5e38\u3092\u4f34\u3046\u3059\u3079\u3066\u306e\u598a\u5a20\u306f\u3001\u598a\u5a20\u7b2c3\u671f\uff08\u3059\u306a\u308f\u3061\u3001\u5668\u5b98\u5f62\u6210\u306e\u671f\u9593\u306e\u304b\u306a\u308a\u5f8c\uff09\u306b\u306e\u307f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306b\u66dd\u9732\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p class=\"f-body--sm\"><span class=\"haiiro\"><label>\u2020\u2020&nbsp;<\/label>Neonatal death indicates death within the first 28 days after delivery.<\/span><br \/>\n<label>\u2020\u2020&nbsp;<\/label>\u65b0\u751f\u5150\u6b7b\u4ea1\u3068\u306f\u3001\u51fa\u7523\u5f8c\u306e\u6700\u521d\u306e28\u65e5\u4ee5\u5185\u306e\u6b7b\u4ea1\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><span class=\"haiiro\">Adverse outcomes among 724 live-born infants \u2014 including 12 sets of multiple gestation \u2014 were preterm birth (60 of 636 among those vaccinated before 37 weeks [9.4%]), small size for gestational age (23 of 724 [3.2%]), and major congenital anomalies (16 of 724 [2.2%]);<\/span><br \/>\n724\u4eba\u306e\u751f\u5150\uff0812\u7d44\u306e\u591a\u80ce\u598a\u5a20\u3092\u542b\u3080\uff09\u306e\u3046\u3061\u3001\u6709\u5bb3\u306a\u8ee2\u5e30\u306f\u3001\u65e9\u7523\uff0837\u9031\u524d\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3057\u305f\u3092\u542b\u3080636\u4eba\u306e\u3046\u306160\u4eba[9.4\uff05]\uff09\u3001\u5728\u80ce\u4e0d\u5f53\u904e\u5c0f\uff08724\u4eba\u4e2d23\u4eba[3.2\uff05]\uff09\u3001\u304a\u3088\u3073\u4e3b\u8981\u306a\u5148\u5929\u6027\u7570\u5e38\uff08724\u4eba\u4e2d16\u4eba[2.2\uff05]\uff09\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">no neonatal deaths were reported at the time of interview.<\/span><br \/>\n\u805e\u304d\u53d6\u308a\u8abf\u67fb\u306e\u6642\u70b9\u3067\u65b0\u751f\u5150\u6b7b\u4ea1\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">Among the participants with completed pregnancies who reported congenital anomalies, none had received Covid-19 vaccine in the first trimester or periconception period, and no specific pattern of congenital anomalies was observed.<\/span><br \/>\n\u5148\u5929\u6027\u7570\u5e38\u3092\u5831\u544a\u3057\u598a\u5a20\u3092\u7d42\u3048\u305f\u53c2\u52a0\u8005\u306e\u4e2d\u3067\u3001\u598a\u5a20\u7b2c1\u671f\u307e\u305f\u306f\u53d7\u80ce\u524d\u5f8c\u306e\u671f\u9593\u306b\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u4eba\u306f\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u5148\u5929\u6027\u7570\u5e38\u306b\u7279\u5b9a\u306e\u30d1\u30bf\u30fc\u30f3\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Calculated proportions of pregnancy and neonatal outcomes appeared similar to incidences published in the peer-reviewed literature (Table 4).<\/span><br \/>\n\u598a\u5a20\u3068\u65b0\u751f\u5150\u8ee2\u5e30\u306e\u5272\u5408\u306f\u3001\u67fb\u8aad\u6e08\u307f\u306e\u6587\u732e\u3067\u767a\u8868\u3055\u308c\u3066\u3044\u308b\u767a\u751f\u7387\u3068\u540c\u69d8\u3068\u601d\u308f\u308c\u307e\u3057\u305f\uff08\u88684\uff09\u3002<\/p>\n<p><strong><span class=\"haiiro\">ADVERSE-EVENT FINDINGS ON THE VAERS<\/span><\/strong><br \/>\n<strong>VAERS\uff08\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\uff09\u306b\u304a\u3051\u308b\u6709\u5bb3\u4e8b\u8c61\u306e\u6240\u898b<\/strong><\/p>\n<p><span class=\"haiiro\">During the analysis period, the VAERS received and processed 221 reports involving Covid-19 vaccination among pregnant persons;<\/span><br \/>\n\u5206\u6790\u671f\u9593\u4e2d\u3001VAERS\u306f\u3001\u598a\u5a66\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u95a2\u3059\u308b221\u4ef6\u306e\uff08\u6709\u5bb3\u4e8b\u8c61\u306e\uff09\u5831\u544a\u3092\u53d7\u3051\u53d6\u308a\u51e6\u7406\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">155 (70.1%) involved nonpregnancy-specific adverse events, and 66 (29.9%) involved pregnancy- or neonatal-specific adverse events (Table S4).<\/span><br \/>\n155\uff0870.1\uff05\uff09\u306f\u975e\u598a\u5a20\u7279\u6709\u306e\u6709\u5bb3\u4e8b\u8c61\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u300166\uff0829.9\uff05\uff09\u306f\u598a\u5a20\u307e\u305f\u306f\u65b0\u751f\u5150\u7279\u6709\u306e\u6709\u5bb3\u4e8b\u8c61\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3057\u305f\uff08\u8868S4\uff09\u3002<\/p>\n<p><span class=\"haiiro\">The most frequently reported pregnancy-related adverse events were spontaneous abortion (46 cases; 37 in the first trimester, 2 in the second trimester, and 7 in which the trimester was unknown or not reported), followed by stillbirth, premature rupture of membranes, and vaginal bleeding, with 3 reports for each.<\/span><br \/>\n\u6700\u3082\u591a\u304f\u5831\u544a\u3055\u308c\u305f\u598a\u5a20\u95a2\u9023\u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u81ea\u7136\u6d41\u7523\uff0846\u4f8b\u3002\u5185\u8a33\u306f\u3001\u7b2c1\u671f\u306b37\u4f8b\u3001\u7b2c2\u671f\u306b2\u4f8b\u3001\u6642\u671f\u4e0d\u660e\u304c7\u4f8b\uff09\u3067\u3042\u308a\u3001\u6b7b\u7523\uff0f\u524d\u671f\u7834\u6c34\uff0f\u4e0d\u6b63\u51fa\u8840\u304c\u305d\u308c\u305e\u308c3\u3064\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">No congenital anomalies were reported to the VAERS, a requirement under the EUAs.<\/span><br \/>\n\u5148\u5929\u6027\u7570\u5e38\u306fVAERS\u306b\u5831\u544a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5148\u5929\u6027\u7570\u5e38\u304c\u7121\u3044\u3053\u3068\u306f\u7dca\u6025\u4f7f\u7528\u8a31\u53ef\uff08EUA\uff09\u306e\u8981\u4ef6\u306e1\u3064\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"big\"><strong><span class=\"haiiro\">Discussion<\/span><\/strong><\/span><br \/>\n<span class=\"big\"><strong>\u8a0e\u8ad6<\/strong><\/span><\/p>\n<hr>\n<p><span class=\"haiiro\">This U.S. surveillance review of the safety of mRNA Covid-19 vaccines during pregnancy and the periconception period indicates that some pregnant persons in the United States are choosing to be vaccinated against Covid-19 in all trimesters of pregnancy.<\/span><br \/>\n\u7c73\u56fd\u306e\u3053\u306e\u8abf\u67fb\u5831\u544a\uff08\u598a\u5a20\u4e2d\u304a\u3088\u3073\u53d7\u80ce\u524d\u5f8c\u306e\u671f\u9593\u306b\u304a\u3051\u308bmRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u306e\u8abf\u67fb\uff09\u306f\u3001\u7c73\u56fd\u3067\u598a\u5a20\u3057\u305f\u4eba\u306e\u4e00\u90e8\u304c\u3001\u598a\u5a20\u671f\u9593\uff08\u7b2c1\u671f\u3001\u7b2c2\u671f\u3001\u7b2c3\u671f\uff09\u306e\u3069\u3053\u304b\u3067\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u3092\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Solicited local and systemic reactions that were reported to the v-safe surveillance system were similar among persons who identified as pregnant and nonpregnant women.<\/span><br \/>\nV-safe\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u306b\u5831\u544a\u3055\u308c\u305f\u975e\u81ea\u767a\u7684\u306a\uff08\u30ef\u30af\u30c1\u30f3\u306e\uff09\u5c40\u6240\u304a\u3088\u3073\u5168\u8eab\u306e\u526f\u53cd\u5fdc\u306f\u3001\u598a\u5a20\u4e2d\u304a\u3088\u3073\u975e\u598a\u5a20\u4e2d\u306e\u5973\u6027\u306e\u9593\u3067\u985e\u4f3c\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Although not directly comparable, the proportions of adverse pregnancy and neonatal outcomes (e.g., fetal loss, preterm birth, small size for gestational age, congenital anomalies, and neonatal death) among participants with completed pregnancies from the v-safe pregnancy registry appear to be similar to the published incidences in pregnant populations studied before the Covid-19 pandemic.<\/span><br \/>\n\u76f4\u63a5\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u304c\u3001V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u3088\u308b\u3068\u3001\u598a\u5a20\u3092\u7d42\u3048\u305f\u53c2\u52a0\u8005\u306e\u6709\u5bb3\u306a\u598a\u5a20\u304a\u3088\u3073\u65b0\u751f\u5150\u8ee2\u5e30\uff08\u80ce\u5150\u306e\u55aa\u5931\u3001\u65e9\u7523\u3001\u5728\u80ce\u4e0d\u5f53\u904e\u5c0f\u3001\u5148\u5929\u6027\u7570\u5e38\u3001\u65b0\u751f\u5150\u6b7b\u4ea1\u306a\u3069\uff09\u306e\u5272\u5408\u306f\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306e\u524d\u306b\u8abf\u67fb\u3055\u308c\u305f\u598a\u5a66\u306b\u304a\u3051\u308b\u767a\u751f\u7387\u3068\u540c\u69d8\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Many participants in the v-safe pregnancy registry were included in the phase 1a (highest) priority group for Covid-19 vaccination owing to their work as health care personnel.<\/span><br \/>\nV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u591a\u304f\u306e\u53c2\u52a0\u8005\u306f\u3001\u533b\u7642\u5f93\u4e8b\u8005\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u305f\u305f\u3081\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u30d5\u30a7\u30fc\u30ba1a\uff08\u6700\u9ad8\uff09\u512a\u5148\u30b0\u30eb\u30fc\u30d7\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">V-safe participation is voluntary, and registration information is not uniformly available at all vaccination locations, although information about the surveillance system is included on the EUA fact sheets for health care providers and patients.<\/span><br \/>\nV-safe\u3078\u306e\u767b\u9332\u306f\u4efb\u610f\u3067\u3042\u308a\u3001\u767b\u9332\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u3059\u3079\u3066\u306e\u4e88\u9632\u63a5\u7a2e\u5834\u6240\u3067\u4e00\u5f8b\u306b\u5165\u624b\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001V-safe\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u533b\u7642\u63d0\u4f9b\u8005\u3068\u60a3\u8005\u5411\u3051\u306e\u7dca\u6025\u4f7f\u7528\u8a31\u53ef\uff08EUA\uff09\u30d5\u30a1\u30af\u30c8\u30b7\u30fc\u30c8\uff08\u91cd\u8981\u4e8b\u9805\u8aac\u660e\u66f8\uff09\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Thus, comparisons of the proportions of vaccinated women with these outcomes to previously published estimates are limited by likely differences between these populations in age, ethnic group, and other social, demographic, and clinical characteristics that are known to be associated with pregnancy and neonatal outcomes.<\/span><br \/>\n\u3057\u305f\u304c\u3063\u3066\u3001\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5973\u6027\u306e\u3053\u308c\u3089\u306e\u8ee2\u5e30\u306e\u5272\u5408\u3068\u3001\u4ee5\u524d\u306b\u767a\u8868\u3055\u308c\u305f\u63a8\u5b9a\u5024\u3068\u306e\u6bd4\u8f03\u306f\u3001\u96c6\u56e3\u306e\u9055\u3044\uff08\u598a\u5a20\u3068\u65b0\u751f\u5150\u8ee2\u5e30\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u5e74\u9f62\u3001\u6c11\u65cf\u3001\u305d\u306e\u4ed6\u306e\u793e\u4f1a\u7684\u7279\u5fb4\u3001\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u7279\u5fb4\u3001\u81e8\u5e8a\u7684\u7279\u5fb4\u306e\u9055\u3044\uff09\u306b\u3088\u3063\u3066\u5236\u9650\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">However, such comparisons are helpful to provide a crude sense of whether there are any unexpected safety signals in these early data.<\/span><br \/>\n\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306e\u6bd4\u8f03\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u521d\u671f\u30c7\u30fc\u30bf\u306b\u4e88\u671f\u305b\u306c\u5371\u967a\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u3001\u5927\u307e\u304b\u306a\u5224\u65ad\u3092\u884c\u3046\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">At the time of this analysis, just 14.7% of persons who identified as pregnant in the v-safe surveillance system had been contacted to offer enrollment in the pregnancy registry.<\/span><br \/>\n\u3053\u306e\u5206\u6790\u306e\u6642\u70b9\u3067\u306f\u3001V-safe\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3067\u598a\u5a66\u3068\u7279\u5b9a\u3055\u308c\u305f\u4eba\u306e\u3046\u3061\u308f\u305a\u304b14.7%\u304c\u3001V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u3078\u306e\u767b\u9332\u3092\u4fc3\u3059\u9023\u7d61\u3092\u53d7\u3051\u3068\u308a\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Other limitations should also be noted.<\/span><br \/>\n\u305d\u306e\u4ed6\u306e\u5236\u9650\u306b\u3082\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">As with all participant-reported surveillance systems, mistakes in completion of v-safe health surveys can result in misclassification of participants as pregnant;<\/span><br \/>\n\u4ed6\u306e\u53c2\u52a0\u8005\u5831\u544a\u578b\u306e\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u3068\u540c\u69d8\u3001V-safe\u5065\u5eb7\u8abf\u67fb\u3067\u5165\u529b\u30df\u30b9\u304c\u3042\u308b\u3068\u3001\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u53c2\u52a0\u8005\u304c\u9593\u9055\u3063\u3066\u598a\u5a66\u3068\u3057\u3066\u5206\u985e\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">as a result, data for local and systemic reactions that participants reported to the v-safe platform may include some reports from nonpregnant persons.<\/span><br \/>\n\u305d\u306e\u7d50\u679c\u3001V-safe\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u53c2\u52a0\u8005\u304b\u3089\u5831\u544a\u3055\u308c\u305f\u5c40\u6240\u304a\u3088\u3073\u5168\u8eab\u306e\u670d\u53cd\u5fdc\u306e\u30c7\u30fc\u30bf\u306b\u306f\u3001\u598a\u5a20\u3057\u3066\u3044\u306a\u3044\u4eba\u304b\u3089\u306e\u5831\u544a\u304c\u542b\u307e\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Participants are not required to complete surveys at the same time every day, and our ability to assess onset or duration of adverse events, such as fever, is limited.<\/span><br \/>\n\u53c2\u52a0\u8005\u306f\u6bce\u65e5\u540c\u3058\u6642\u9593\u306b\u8abf\u67fb\u3092\u5b8c\u4e86\u3059\u308b\u5fc5\u8981\u306f\u306a\u3044\u305f\u3081\u3001\u767a\u71b1\u306a\u3069\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u75c7\u3084\u671f\u9593\u3092\u8a55\u4fa1\u3059\u308b\u306b\u306f\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">The registry data are preliminary, are from a small sample, and describe mostly neonatal outcomes from third-trimester vaccination;<\/span><br \/>\n\u767b\u9332\u30c7\u30fc\u30bf\u306f\u4e88\u5099\u7684\u306a\u3082\u306e\u3067\u3042\u308a\u3001\u30b5\u30f3\u30d7\u30eb\u306f\u5c11\u6570\u3067\u3042\u308a\u3001\u4e3b\u306b\u598a\u5a20\u306e\u7b2c3\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5834\u5408\u306e\u65b0\u751f\u5150\u306e\u8ee2\u5e30\u306b\u3064\u3044\u3066\u8aac\u660e\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">the findings may change as additional pregnancy outcomes are reported and the sample size increases, which may facilitate detection of rare outcomes.<\/span><br \/>\n\u3088\u308a\u591a\u304f\u306e\u598a\u5a20\u8ee2\u5e30\u304c\u5831\u544a\u3055\u308c\u3001\u30b5\u30f3\u30d7\u30eb\u306e\u6570\u304c\u5897\u3048\u308b\u3068\u3001\u8abf\u67fb\u7d50\u679c\u304c\u5909\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u307e\u308c\u306a\u8ee2\u5e30\u306e\u767a\u898b\u306b\u3064\u306a\u304c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">We were unable to evaluate adverse outcomes that might occur in association with exposures earlier in pregnancy, such as congenital anomalies, because no pregnant persons who were vaccinated early in pregnancy have had live births captured in the v-safe pregnancy registry to date; follow-up is ongoing.<\/span><br \/>\n\u598a\u5a20\u521d\u671f\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306b\u3088\u3063\u3066\u8d77\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u6709\u5bb3\u306a\u7d50\u679c\uff08\u5148\u5929\u6027\u7570\u5e38\u306a\u3069\uff09\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u598a\u5a20\u521d\u671f\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u598a\u5a66\u304c\u3001\u73fe\u5728\u306e\u3068\u3053\u308d\u3001V-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u51fa\u751f\u3092\u8a18\u9332\u3057\u3066\u3044\u306a\u3044\u305f\u3081\u3067\u3059\u3002\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306f\u5f15\u304d\u7d9a\u304d\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">In addition, the proportion of pregnant persons who reported spontaneous abortion may not reflect true postvaccination proportions because participants might have been vaccinated after the period of greatest risk in the first trimester, and very early pregnancy losses might not be recognized.<\/span><br \/>\n\u3055\u3089\u306b\u3001\u81ea\u7136\u6d41\u7523\u3092\u5831\u544a\u3057\u305f\u598a\u5a66\u306e\u5272\u5408\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u5b9f\u969b\u306e\u5272\u5408\u3092\u53cd\u6620\u3057\u3066\u3044\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u306a\u305c\u306a\u3089\u3001\u53c2\u52a0\u8005\u304c\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u306e\u306f\u3001\u598a\u5a20\u7b2c1\u671f\u306e\u6700\u3082\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u671f\u9593\u306e\u5f8c\u3060\u3063\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u975e\u5e38\u306b\u65e9\u3044\u6642\u671f\u306e\u598a\u5a20\u55aa\u5931\u304c\u8a8d\u8b58\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Whereas some pregnancies with vaccination in the first and early second trimester have been completed, the majority are ongoing,<\/span><br \/>\n\u598a\u5a20\u7b2c1\u671f\u3068\u7b2c2\u671f\u306e\u521d\u671f\u306b\u4e88\u9632\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u4e00\u90e8\u306e\u598a\u5a66\u306e\u598a\u5a20\u304c\u7d42\u308f\u3063\u305f\u4e00\u65b9\u3067\u3001\u5927\u90e8\u5206\u306f\u307e\u3060\u598a\u5a20\u4e2d\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">and a direct comparison of outcomes on the basis of timing of vaccination is needed to define the proportion of spontaneous abortions in this cohort.<\/span><br \/>\n\u3053\u306e\u96c6\u56e3\uff08\u30b3\u30db\u30fc\u30c8\uff09\u306b\u304a\u3051\u308b\u81ea\u7136\u6d41\u7523\u306e\u5272\u5408\u3092\u5b9a\u7fa9\u3059\u308b\u306b\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u57fa\u3065\u3044\u305f\u7d50\u679c\u3092\u76f4\u63a5\u6bd4\u8f03\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Because of sample-size constraints, both pregnancy and neonatal outcomes were calculated as a proportion instead of a rate.<\/span><br \/>\n\u30b5\u30f3\u30d7\u30eb\u6570\u306e\u5236\u7d04\u306e\u305f\u3081\u3001\u598a\u5a20\u3068\u65b0\u751f\u5150\u306e\u4e21\u65b9\u306e\u7d50\u679c\u306f\u3001rate\uff08\u7279\u5b9a\u671f\u9593\u5185\u306e\u983b\u5ea6\uff09\u3067\u306f\u306a\u304fproportion\uff08\u7279\u5b9a\u96c6\u56e3\u5185\u306e\u5272\u5408\uff09\u3068\u3057\u3066\u7b97\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">Our preliminary analysis uses participant-reported data and has limited information on other potential risk factors for adverse pregnancy and neonatal outcomes.<\/span><br \/>\n\u79c1\u305f\u3061\u306e\u4e88\u5099\u5206\u6790\u3067\u306f\u3001\u53c2\u52a0\u8005\u304b\u3089\u5831\u544a\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u305d\u306e\u4ed6\u306e\u6709\u5bb3\u306a\u598a\u5a20\u3084\u65b0\u751f\u5150\u8ee2\u5e30\u306b\u3064\u3044\u3066\u306e\u6f5c\u5728\u7684\u306a\u5371\u967a\u56e0\u5b50\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">The VAERS is subject to the limitations of passive surveillance.<\/span><br \/>\nVAERS\u306b\u306f\u53d7\u52d5\u7684\u8abf\u67fb\u306b\u7279\u6709\u306e\u5236\u9650\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Despite EUA mandatory reporting requirements and CDC guidance on VAERS reporting, there is probably substantial underreporting of pregnancy- and neonatal-specific adverse events.<\/span><br \/>\n\u7dca\u6025\u4f7f\u7528\u8a31\u53ef\uff08EUA\uff09\u306e\u7fa9\u52d9\u7684\u306a\u5831\u544a\u8981\u8acb\u3068VAERS\u3078\u306e\u5831\u544a\u3092\u4fc3\u3059CDC\u306e\u30ac\u30a4\u30c0\u30f3\u30b9\u304c\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u304a\u305d\u3089\u304f\u3001\u598a\u5a20\u304a\u3088\u3073\u65b0\u751f\u5150\u7279\u6709\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u3001\u304b\u306a\u308a\u904e\u5c11\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">We also do not know the total number of Covid-19 vaccine doses administered to pregnant persons, which further limits our ability to estimate rates of reported adverse events from VAERS data.<\/span><br \/>\n\u307e\u305f\u3001\u598a\u5a20\u4e2d\u306e\u4eba\u306b\u63a5\u7a2e\u3055\u308c\u305f\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u7dcf\u6570\u3082\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u5f93\u3063\u3066\u3001VAERS\u30c7\u30fc\u30bf\u304b\u3089\u5831\u544a\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u3092\u63a8\u5b9a\u3059\u308b\u3053\u3068\u304c\u3055\u3089\u306b\u96e3\u3057\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Among pregnancy-specific conditions reported to the VAERS after Covid-19 vaccination, miscarriage was the most common.<\/span><br \/>\n\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306b\u3001VAERS\u306b\u5831\u544a\u3055\u308c\u305f\u598a\u5a20\u7279\u6709\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u3046\u3061\u6700\u3082\u4e00\u822c\u7684\u3060\u3063\u305f\u306e\u306f\u3001\u6d41\u7523\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">This is similar to what was observed during the influenza A (H1N1) pandemic in 2009 after the introduction of the 2009 H1N1 inactivated influenza vaccine, where miscarriage was the most common adverse event reported by pregnant persons who received that vaccine.<\/span><br \/>\n\u3053\u308c\u306f\u30012009\u5e74\u306eH1N1\u4e0d\u6d3b\u5316\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u306e\u5c0e\u5165\u5f8c\u306b\u3001\u540c\u5e74\u306b\u8d77\u304d\u305f\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6A\uff08H1N1\uff09\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u4e2d\u306b\u89b3\u5bdf\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\u3068\u4f3c\u3066\u3044\u307e\u3059\u3002\u6d41\u7523\u306f\u3001H1N1\u4e0d\u6d3b\u5316\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u598a\u5a66\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u3001\u6700\u3082\u4e00\u822c\u7684\u306a\u6709\u5bb3\u4e8b\u8c61\u3067\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">In addition to vaccination protecting women against Covid-19 and its complications during pregnancy, emerging evidence has shown transplacental transfer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies after maternal Covid-19 vaccination during the third trimester,<\/span><br \/>\n\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u3068\u65b0\u578b\u30b3\u30ed\u30ca\u306b\u3088\u308b\u598a\u5a20\u4e2d\u306e\u5408\u4f75\u75c7\u304b\u3089\u5973\u6027\u3092\u5b88\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u3055\u3089\u306b\u3001\u598a\u5a20\u7b2c3\u671f\u306b\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u6bcd\u89aa\u304b\u3089\u3001\u80ce\u76e4\u3092\u901a\u3058\u3066\u80ce\u5150\u306b\u3082\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u3078\u306e\u6297\u4f53\u304c\u53d7\u3051\u7d99\u304c\u308c\u305f\u3068\u3044\u3046\u65b0\u305f\u306a\u8a3c\u62e0\u304c\u898b\u3064\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">which suggests that maternal vaccination might provide some level of protection to the neonate.<\/span><br \/>\n\u3053\u308c\u306f\u3064\u307e\u308a\u3001\u6bcd\u89aa\u304c\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u65b0\u751f\u5150\u3092\u3042\u308b\u7a0b\u5ea6\u5b88\u308b\u52b9\u679c\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">However, we do not have data on antibody transfer and level of protection relative to the timing of vaccination.<\/span><br \/>\n\u3057\u304b\u3057\u3001\u6297\u4f53\u306e\u79fb\u52d5\u3068\u9632\u5fa1\u52b9\u679c\u3092\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u95a2\u9023\u4ed8\u3051\u305f\u30c7\u30fc\u30bf\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">The CDC and the FDA are continuing to monitor and disseminate information about the safety of mRNA and additional types of Covid-19 vaccines in pregnant persons.<\/span><br \/>\nCDC\u3068FDA\u306f\u3001\u598a\u5a66\u306b\u5bfe\u3059\u308bmRNA\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u76e3\u8996\u3068\u5468\u77e5\u3092\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Early data from the v-safe surveillance system, the v-safe pregnancy registry, and the VAERS do not indicate any obvious safety signals with respect to pregnancy or neonatal outcomes associated with Covid-19 vaccination in the third trimester of pregnancy.<\/span><br \/>\nV-safe\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\uff0fV-safe\u598a\u5a20\u30ec\u30b8\u30b9\u30c8\u30ea\uff0fVAERS\u306e\u521d\u671f\u306e\u30c7\u30fc\u30bf\u306b\u3088\u308c\u3070\u3001\u598a\u5a20\u7b2c3\u671f\u306b\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u5834\u5408\u306b\u304a\u3044\u3066\u3001\u598a\u5a20\u307e\u305f\u306f\u65b0\u751f\u5150\u306e\u8ee2\u5e30\u306b\u5bfe\u3059\u308b\u660e\u3089\u304b\u306a\u5b89\u5168\u6027\u306e\u61f8\u5ff5\u306f\u793a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">Continued monitoring is needed to further assess maternal, pregnancy, neonatal, and childhood outcomes associated with maternal Covid-19 vaccination, including in earlier stages of pregnancy and during the preconception period.<\/span><br \/>\n\u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u305f\u598a\u5a66\u306b\u3064\u3044\u3066\u3001\u598a\u5a20\u521d\u671f\u3084\u53d7\u80ce\u524d\u306e\u671f\u9593\u3092\u542b\u3081\u3066\u305d\u306e\u6bcd\u89aa\uff0f\u598a\u5a20\uff0f\u65b0\u751f\u5150\uff0f\u5c0f\u5150\u306e\u8ee2\u5e30\u3092\u3055\u3089\u306b\u8a55\u4fa1\u3059\u308b\u306b\u306f\u3001\u7d99\u7d9a\u7684\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p><span class=\"haiiro\">Meanwhile, the present data can help inform decision making about vaccination by pregnant persons and their health care providers.<\/span><br \/>\n\u4e00\u65b9\u3001\u73fe\u5728\u306e\u30c7\u30fc\u30bf\u306f\u3001\u598a\u5a20\u4e2d\u306e\u4eba\u3068\u305d\u306e\u533b\u7642\u63d0\u4f9b\u8005\u304c\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u53ef\u5426\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306e\u60c5\u5831\u3068\u3057\u3066\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr>\n<p><span class=\"haiiro\">Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.<\/span><br \/>\n\u8457\u8005\u306b\u3088\u3063\u3066\u63d0\u4f9b\u3055\u308c\u305f\u958b\u793a\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u3053\u306e\u8a18\u4e8b\u306e\u5168\u6587\u3068\u3068\u3082\u306b\u3001NEJM.org\u3067\u5165\u624b\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC) or the Food and Drug Administration (FDA).<\/span><br \/>\n\u3053\u306e\u8a18\u4e8b\u306e\u8abf\u67fb\u7d50\u679c\u3068\u7d50\u8ad6\u306f\u8457\u8005\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u7c73\u56fd\u75be\u75c5\u4e88\u9632\u7ba1\u7406\u30bb\u30f3\u30bf\u30fc\uff08CDC\uff09\u307e\u305f\u306f\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306e\u516c\u5f0f\u306e\u7acb\u5834\u3092\u8868\u3057\u3066\u3044\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">Mention of a product or company name is for identification purposes only and does not constitute endorsement by the CDC or the FDA.<\/span><br \/>\n\u88fd\u54c1\u540d\u307e\u305f\u306f\u4f1a\u793e\u540d\u306e\u8a18\u8f09\u306f\u8b58\u5225\u306e\u307f\u3092\u76ee\u7684\u3068\u3057\u3066\u304a\u308a\u3001CDC\u307e\u305f\u306fFDA\u306b\u3088\u308b\u627f\u8a8d\u3092\u610f\u5473\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">All authors are U.S. government employees or U.S. government contractors and do not have any material conflicts of interest.<\/span><br \/>\n\u8457\u8005\u306e\u5168\u54e1\u306f\u7c73\u56fd\u653f\u5e9c\u8077\u54e1\u307e\u305f\u306f\u7c73\u56fd\u653f\u5e9c\u8acb\u8ca0\u696d\u8005\u3067\u3042\u308a\u3001\u91cd\u5927\u306a\u5229\u76ca\u76f8\u53cd\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><span class=\"haiiro\">Oracle provided in-kind technical support to build and maintain the v-safe after vaccination health checker infrastructure for data capture and messaging to participants.<\/span><br \/>\n\u53c2\u52a0\u8005\u306e\u30c7\u30fc\u30bf\u53ce\u96c6\u3068\u30e1\u30c3\u30bb\u30fc\u30b8\u306e\u9001\u4fe1\u3092\u884c\u3046V-safe\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u30d8\u30eb\u30b9\u30c1\u30a7\u30c3\u30ab\u30fc\u306e\u69cb\u7bc9\u3068\u4fdd\u5b88\u306b\u3064\u3044\u3066\u3001Oracle\u304b\u3089\u6280\u8853\u30b5\u30dd\u30fc\u30c8\u3092\u3054\u63d0\u4f9b\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">This article was published on April 21, 2021, at NEJM.org.<\/span><br \/>\n\u3053\u306e\u8a18\u4e8b\u306f\u30012021\u5e744\u670821\u65e5\u306bNEJM.org\u3067\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span class=\"haiiro\">A data sharing statement provided by the authors is available with the full text of this article at NEJM.org.<\/span><br \/>\n\u8457\u8005\u304b\u3089\u63d0\u4f9b\u3055\u308c\u305f\u30c7\u30fc\u30bf\u5171\u6709\u306e\u58f0\u660e\u306f\u3001\u3053\u306e\u8a18\u4e8b\u306e\u5168\u6587\u3068\u5171\u306bNEJM.org\u3067\u95b2\u89a7\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><span class=\"haiiro\">We thank the v-safe participants, the members of the Oracle v-safe development team for their contributions, and the members of the CDC COVID-19 Response Team for their support.<\/span><br \/>\nV-safe\u306e\u53c2\u52a0\u8005\u3001Oracle V-safe\u958b\u767a\u30c1\u30fc\u30e0\u30e1\u30f3\u30d0\u30fc\u306e\u8ca2\u732e\u3001\u305d\u3057\u3066CDC\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u5fdc\u7b54\u30c1\u30fc\u30e0\u306e\u30e1\u30f3\u30d0\u30fc\u306e\u30b5\u30dd\u30fc\u30c8\u306b\u3001\u611f\u8b1d\u3092\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<\/p>\n<h2 id=\"i-9\"><span class=\"ez-toc-section\" id=\"%E3%81%9D%E3%81%AE%E4%BB%96%E3%81%AE%E5%8F%82%E8%80%83%E8%A8%98%E4%BA%8B\"><\/span>\u305d\u306e\u4ed6\u306e\u53c2\u8003\u8a18\u4e8b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 id=\"i-10\"><span class=\"ez-toc-section\" id=\"mRNA%E3%83%AF%E3%82%AF%E3%83%81%E3%83%B3%E6%8E%A5%E7%A8%AE%E3%81%A782%E6%B5%81%E7%94%A3%E3%81%AE%E3%83%87%E3%83%9E%EF%BC%88kj%E6%B0%8F%EF%BC%89\"><\/span>mRNA\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306782%\u6d41\u7523\u306e\u30c7\u30de\uff08kj\u6c0f\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/note.com\/kj62824378\/n\/nbc7b45ac1328\" target=\"_blank\" rel=\"noopener\">https:\/\/note.com\/kj62824378\/n\/nbc7b45ac1328<\/a><\/p>\n<h3 id=\"i-11\"><span class=\"ez-toc-section\" id=\"%E3%83%AF%E3%82%AF%E3%83%81%E3%83%B3%E3%81%A7%E5%A6%8A%E5%A9%A6%E3%81%AE82%E3%81%8C%E6%B5%81%E7%94%A3%E3%81%99%E3%82%8B%E3%81%A8%E3%81%84%E3%81%86%E3%83%87%E3%83%9E%E3%81%A8%E3%82%BD%E3%83%BC%E3%82%B9%E8%AB%96%E6%96%87%E3%81%AE%E8%AA%AD%E8%A7%A3%EF%BC%88pogemutaBN%E6%B0%8F%EF%BC%89\"><\/span>\u30ef\u30af\u30c1\u30f3\u3067\u598a\u5a66\u306e82%\u304c\u6d41\u7523\u3059\u308b\u3068\u3044\u3046\u30c7\u30de\u3068\u30bd\u30fc\u30b9\u8ad6\u6587\u306e\u8aad\u89e3\uff08pogemutaBN\u6c0f\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/togetter.com\/li\/1741653\" target=\"_blank\" rel=\"noopener\">\u30ef\u30af\u30c1\u30f3\u3067\u598a\u5a66\u306e82%\u304c\u6d41\u7523\u3059\u308b\u3068\u3044\u3046\u30c7\u30de\u3068\u30bd\u30fc\u30b9\u8ad6\u6587\u306e\u8aad\u89e3<\/a><\/p>\n<h3 id=\"i-12\"><span class=\"ez-toc-section\" id=\"%E3%80%8CNEJM%E8%AB%96%E6%96%87%E3%81%AB%E3%82%88%E3%82%8C%E3%81%B0%E3%83%AF%E3%82%AF%E3%83%81%E3%83%B3%E6%8E%A5%E7%A8%AE%E3%82%92%E5%8F%97%E3%81%91%E3%81%9F%E5%A6%8A%E5%A9%A6%E3%81%AE%E6%B5%81%E7%94%A3%E7%8E%87%E3%81%8C82%EF%BC%85%E3%80%8D%E3%81%AF%E3%83%87%E3%83%9E%EF%BC%88%E4%BC%8A%E8%B3%80%E6%B2%BB%E6%B0%8F%EF%BC%89\"><\/span>\u300cNEJM\u8ad6\u6587\u306b\u3088\u308c\u3070\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u598a\u5a66\u306e\u6d41\u7523\u7387\u304c82\uff05\u300d\u306f\u30c7\u30de\uff08\u4f0a\u8cc0\u6cbb\u6c0f\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/note.com\/osamu_iga\/n\/n76735f6e16ca?magazine_key=mb5506dd546a0\" target=\"_blank\" rel=\"noopener\">\u300cNEJM\u8ad6\u6587\u306b\u3088\u308c\u3070\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u598a\u5a66\u306e\u6d41\u7523\u7387\u304c82\uff05\u300d\u306f\u30c7\u30de\uff08\u4f0a\u8cc0\u6cbb\u6c0f\uff09<\/a><\/p>\n<h3 id=\"i-13\"><span class=\"ez-toc-section\" id=\"Fact_Check-Data_from_a_study_does_not_conclude_that_over_80_of_pregnancies_end_in_miscarriage_after_COVID-19_vaccinations_figures_taken_out_of_context%EF%BC%88REUTERS%EF%BC%89\"><\/span>Fact Check-Data from a study does not conclude that over 80% of pregnancies end in miscarriage after COVID-19 vaccinations; figures taken out of context\uff08REUTERS\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/reut.rs\/3kHampx\" target=\"_blank\" rel=\"noopener\">https:\/\/reut.rs\/3kHampx<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u691c\u7d22\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\uff18\uff12\u30d1\u30fc\u30bb\u30f3\u30c8<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30c7\u30de\u306e\u5185\u5bb9 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<\/p>\n","protected":false},"author":2,"featured_media":5559,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,5,8],"tags":[],"class_list":{"0":"post-6089","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-covid-19","8":"category-5","9":"category-8","10":"entry"},"_links":{"self":[{"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=\/wp\/v2\/posts\/6089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6089"}],"version-history":[{"count":3,"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=\/wp\/v2\/posts\/6089\/revisions"}],"predecessor-version":[{"id":12151,"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=\/wp\/v2\/posts\/6089\/revisions\/12151"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=\/wp\/v2\/media\/5559"}],"wp:attachment":[{"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hoe2021.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}